M
Michael W. Salter
Researcher at University of Toronto
Publications - 212
Citations - 29844
Michael W. Salter is an academic researcher from University of Toronto. The author has contributed to research in topics: NMDA receptor & Neuropathic pain. The author has an hindex of 76, co-authored 182 publications receiving 26667 citations. Previous affiliations of Michael W. Salter include Kyushu University & Mental Health Research Institute.
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The role of the immune system in Alzheimer disease: Etiology and treatment.
TL;DR: This review seeks to demonstrate how various aspects of the immune system, both in the brain and peripherally, interact to contribute to AD.
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Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn
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ATP causes release of intracellular Ca2+ via the phospholipase C beta/IP3 pathway in astrocytes from the dorsal spinal cord
Michael W. Salter,J. L. Hicks +1 more
TL;DR: The results indicate that in astrocytes ATP-evoked release of intracellular Ca2+ is mediated by IP3 produced as a result of activating phospholipase C coupled to ATP receptors via a G-protein that is insensitive to pertussis toxin.
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Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier
TL;DR: It is discovered that injury to a peripheral nerve and electrical stimulation of C-fibers each cause an increase in the permeability of the BSCB and the BBB, and the most parsimonious explanation is that the increase in permeability is mediated by activation of TRPV1-expressing primary sensory neurons.
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Sex differences in pain: a tale of two immune cells.
TL;DR: Despite similar microglia proliferation in the dorsal horn in both sexes, females do not upregulate P2X4Rs and use a microglIA-independent pathway to mediate pain hypersensitivity in female mice, highlighting the importance of including subjects of both sexes in preclinical pain research.