M
Michael W. Salter
Researcher at University of Toronto
Publications - 212
Citations - 29844
Michael W. Salter is an academic researcher from University of Toronto. The author has contributed to research in topics: NMDA receptor & Neuropathic pain. The author has an hindex of 76, co-authored 182 publications receiving 26667 citations. Previous affiliations of Michael W. Salter include Kyushu University & Mental Health Research Institute.
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Journal ArticleDOI
NMDA receptors in clinical neurology: excitatory times ahead
TL;DR: There are other NMDAR-targeted therapies used in current practice that are effective for treating some neurological disorders and the evidence for the use of these therapies is described and an overview of drugs being investigated in clinical trials is provided.
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Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses
Yang Zhong Huang,Yang Zhong Huang,Yang Zhong Huang,Sandra Won,Declan W. Ali,Qiang Wang,Qiang Wang,Qiang Wang,Michael Tanowitz,Quan S. Du,Kenneth A Pelkey,Da-Jun Yang,Wen Cheng Xiong,Michael W. Salter,Lin Mei,Lin Mei +15 more
TL;DR: NRG suppressed induction of long-term potentiation in the hippocampal CA1 region without affecting basal synaptic transmission, suggesting that NRG signaling may be synaptic and regulated by PSD-95.
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Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice
Robert E. Sorge,Michael L. LaCroix-Fralish,Alexander H. Tuttle,Susana G. Sotocinal,Jean-Sebastien Austin,Jennifer Ritchie,Mona Lisa Chanda,Allyson C. Graham,Lucas Topham,Simon Beggs,Michael W. Salter,Jeffrey S. Mogil +11 more
TL;DR: It is found that activating TLR4 in the spinal cord, with the agonist lipopolysaccharide (LPS), causes robust mechanical allodynia but only in male mice, and no sex differences in spinal Tlr4 gene expression at baseline or after LPS is found, suggesting the existence of parallel spinal pain-processing circuitry in female mice not involvingTLR4.
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Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.
Francesco Ferrini,Francesco Ferrini,Tuan Trang,Theresa-Alexandra M Mattioli,Sophie Laffray,Thomas Del’Guidice,Louis-Etienne Lorenzo,Annie Castonguay,Nicolas Doyon,Wen-Bo Zhang,Antoine G. Godin,Daniela Mohr,Simon Beggs,Karen Vandal,Jean-Martin Beaulieu,Catherine M. Cahill,Catherine M. Cahill,Michael W. Salter,Yves De Koninck +18 more
TL;DR: The findings dissociate morphine-induced hyperalgesia from tolerance and suggest the microglia-to-neuron P2X4-BDNF-KCC2 pathway as a therapeutic target for preventing hyperalGESia without affecting morphine analgesia.
Journal ArticleDOI
TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.
Rozita Razavi,Yin Chan,F. Nikoo Afifiyan,Xue Jun Liu,Xiang Wan,Jason Yantha,Hubert Tsui,Lan Tang,Sue Tsai,Pere Santamaria,John P. Driver,David V. Serreze,Michael W. Salter,H.-Michael Dosch +13 more
TL;DR: A fundamental role for insulin-responsive TRPV1(+) sensory neurons in beta cell function and diabetes pathoetiology is uncovered and delivered by intra-arterial injection into the NOD pancreas reverses abnormal insulin resistance, insulitis, and diabetes for weeks.