M
Michael Wegmann
Researcher at University of Marburg
Publications - 69
Citations - 2546
Michael Wegmann is an academic researcher from University of Marburg. The author has contributed to research in topics: Asthma & Inflammation. The author has an hindex of 25, co-authored 60 publications receiving 2197 citations.
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Journal ArticleDOI
Airway remodeling in asthma: what really matters.
TL;DR: This review will address a few major aspects: what are reliable quantitative approaches to assess airway remodeling, and are there any indications supporting the notion that airways remodeling can occur as a primary event, i.e., before any inflammatory process was initiated?
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Prenatal lipopolysaccharide-exposure prevents allergic sensitization and airway inflammation, but not airway responsiveness in a murine model of experimental asthma.
TL;DR: An inverse correlation between lipopolysaccharide exposure and development of childhood allergy has been found and it is found that prenatal environmental factors contribute to the development of postnatal allergies.
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Within-subject variability and per cent change for significance of spirometry in normal subjects and in patients with cystic fibrosis.
TL;DR: The coefficient of variations of spirometry were smallest for forced vital capacity, forced expiratory volume in one second (FEV1), and peak flow (PF), and were largest for root moments (M) and slope ratios (SR) in both normal subjects and patients with CF.
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Allergic Airway Inflammation Inhibits Pulmonary Antibacterial Host Defense
Christoph Beisswenger,Kerstin Kandler,C. Hess,Holger Garn,Kerstin Felgentreff,Michael Wegmann,Harald Renz,Claus Vogelmeier,Robert Bals +8 more
TL;DR: Results show that an allergic airway inflammation suppresses the innate antimicrobial host defense during bacterial infection, and the adaptive immune system modulates the functions of the pulmonary innate immune system.
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IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice
Lars Lunding,Sina Webering,Christina Vock,Alexandra Schröder,Diana Raedler,Bianca Schaub,Heinz Fehrenbach,Michael Wegmann +7 more
TL;DR: The effects of IL‐37 on allergic airway inflammation in a mouse model of experimental asthma is studied to investigate the effects of this negative regulator of innate immunity on human asthma pathogenesis.