C
Christina Wagner
Researcher at Medical University of Vienna
Publications - 35
Citations - 863
Christina Wagner is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 13, co-authored 26 publications receiving 650 citations. Previous affiliations of Christina Wagner include University of Kiel & Charité.
Papers
More filters
Journal ArticleDOI
Airway remodeling in asthma: what really matters.
TL;DR: This review will address a few major aspects: what are reliable quantitative approaches to assess airway remodeling, and are there any indications supporting the notion that airways remodeling can occur as a primary event, i.e., before any inflammatory process was initiated?
Journal ArticleDOI
Molecular architecture of the fruit fly's airway epithelial immune system
TL;DR: The innate immune system of the fly's airway epithelium has a very peculiar organization, where a great variety of pattern recognition receptors as well as of potential effector molecules are conspicuous, whereas signalling presumably occurs through a single NF-κB activating pathway.
Journal ArticleDOI
Molecular and pharmacodynamic characteristics of the novel multi-target tumor growth inhibitor ZK 304709.
Gerhard Siemeister,Ulrich Luecking,Christina Wagner,Katharina Detjen,C. Mc Coy,Klaus Bosslet +5 more
TL;DR: In this article, a nanomolar inhibitor of cyclin-dependent kinases 1, 2, 4, 7 and 9, as well as vascular endothelial growth factor receptor tyrosine kinase 1-3 and platelet-derived growth Factor receptor beta tyrosINE kinase.
Journal ArticleDOI
Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination.
Xuan-Hung Nguyen,Philipp A. Lang,Karl S. Lang,Dieter Adam,Gulnar Fattakhova,Niko Föger,Mohammad Azhar Kamal,Patricia Prilla,Sabine Mathieu,Christina Wagner,Tak W. Mak,Andrew C. Chan,Kyeong-Hee Lee +12 more
TL;DR: It is demonstrated that the immune specific cell surface molecule Toso exhibits antiapoptotic effects on death receptor signaling by a novel regulatory mechanism involving the adaptor kinase RIP1, opening up new therapeutic prospects for the treatment of immune disorders and hematologic malignancies.
Journal ArticleDOI
Fibroblast Growth Factor Receptor Inhibition Is Active against Mesothelioma and Synergizes with Radio- and Chemotherapy
Karin Schelch,Mir Alireza Hoda,Thomas Klikovits,Julia Münzker,Bahil Ghanim,Christina Wagner,Tamás Garay,Viktoria Laszlo,Ulrike Setinek,Balazs Dome,Martin Filipits,Christine Pirker,Petra Heffeter,Edgar Selzer,József Tóvári,Szilvia Török,István Kenessey,Klaus Holzmann,Bettina Grasl-Kraupp,Brigitte Marian,Walter Klepetko,Walter Berger,Balazs Hegedus,Michael Grusch +23 more
TL;DR: The data suggest that the malignant phenotype of mesothelioma cells depends on intact FGF signals, which should be considered as therapeutic targets with a promising chemo- and radiosensitizing potential.