H
Holger Garn
Researcher at University of Marburg
Publications - 137
Citations - 6514
Holger Garn is an academic researcher from University of Marburg. The author has contributed to research in topics: Asthma & Allergy. The author has an hindex of 43, co-authored 129 publications receiving 5555 citations.
Papers
More filters
Journal ArticleDOI
Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78.
Melanie L. Conrad,Ruth Ferstl,R. Teich,Stephanie Brand,Nicole Blümer,Ali Oender Yildirim,Cecilia C. Patrascan,Anna Hanuszkiewicz,Shizuo Akira,Hermann Wagner,Otto Holst,Erika von Mutius,Petra Ina Pfefferle,Carsten J. Kirschning,Holger Garn,Harald Renz +15 more
TL;DR: Data establish a direct relationship between maternal bacterial exposures, functional maternal TLR signaling, and asthma protection in the progeny, and the involvement of Toll-like receptor (TLR) signaling in prenatal protection from asthma.
Journal ArticleDOI
Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice
Michael Seimetz,Nirmal Parajuli,Alexandra Pichl,Florian Veit,Grazyna Kwapiszewska,Friederike C. Weisel,Katrin Milger,Bakytbek Egemnazarov,Agnieszka Turowska,Beate Fuchs,Sandeep Nikam,Markus Roth,Akylbek Sydykov,Thomas Medebach,Walter Klepetko,Peter Jaksch,Rio Dumitrascu,Holger Garn,Robert Voswinckel,Sawa Kostin,Werner Seeger,Ralph T. Schermuly,Friedrich Grimminger,Hossein Ardeschir Ghofrani,Norbert Weissmann +24 more
TL;DR: Treatment of wild-type mice with the iNOS inhibitor N(6)-(1-iminoethyl)-L-lysine (L-NIL) prevented structural and functional alterations of both the lung vasculature and alveoli and also reversed established disease.
Journal ArticleDOI
Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme.
Norbert Krug,Jens M. Hohlfeld,Anne-Marie Kirsten,Oliver Kornmann,Kai Michael Beeh,Dominik Kappeler,Stephanie Korn,Stanislav Ignatenko,Wolfgang Timmer,Cordelia Rogon,Jana Zeitvogel,Nan Zhang,Joachim Bille,Ursula Homburg,Agnieszka Turowska,Claus Bachert,Thomas Werfel,Roland Buhl,Jonas Renz,Holger Garn,Harald Renz +20 more
TL;DR: Treatment with SB010 significantly attenuated both late and early asthmatic responses after allergen provocation in patients with allergic asthma, and biomarker analysis showed an attenuation of Th2-regulated inflammatory responses.
Journal ArticleDOI
Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties
Jennifer Debarry,Holger Garn,Anna Hanuszkiewicz,Nina Dickgreber,Nicole Blümer,Erika von Mutius,Albrecht Bufe,Sören Gatermann,Harald Renz,Otto Holst,Holger Heine +10 more
TL;DR: The data strongly support the hygiene hypothesis, which states that an environment rich in microbiologic structures, such as a farming environment, might protect against the development of allergies.
Journal ArticleDOI
Early nutrition and immunity – progress and perspectives
Philip C. Calder,Susanne Krauss-Etschmann,Esther C. de Jong,Christophe Dupont,Julia-Stefanie Frick,Hanne Frøkiær,Joachim Heinrich,Holger Garn,Sibylle Koletzko,Gideon Lack,Gianluca Mattelio,Harald Renz,Per T. Sangild,Jürgen Schrezenmeir,Thomas M. Stulnig,Thomas Thymann,Agnes E. Wold,Berthold Koletzko +17 more
TL;DR: The development of tolerance is the result of active immune mechanisms and both development and maintenance of tolerance are lifelong processes which start very early in life, even prenatally as mentioned in this paper, and a breakdown in the tolerogenic pathways can also lead to inflammatory diseases.