M
Michel Cuenod
Researcher at University of Lausanne
Publications - 161
Citations - 10925
Michel Cuenod is an academic researcher from University of Lausanne. The author has contributed to research in topics: Glutathione & Oxidative stress. The author has an hindex of 58, co-authored 159 publications receiving 10032 citations. Previous affiliations of Michel Cuenod include University of Zurich & University Hospital of Lausanne.
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Journal ArticleDOI
Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo.
Kim Q. Do,Andreas Trabesinger,M. Kirsten-Krüger,C. J. Lauer,Ulrike Dydak,D. Hell,Florian Holsboer,Peter Boesiger,Michel Cuenod +8 more
TL;DR: In cerebrospinal fluid of drug‐free schizophrenic patients, a significant decrease in the level of total glutathione (GSH) was observed, in keeping with the reported reduced level of its metabolite γ‐glutamylglutamine.
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N-acetyl cysteine as a glutathione precursor for schizophrenia--a double-blind, randomized, placebo-controlled trial.
Michael Berk,David L. Copolov,David L. Copolov,Olivia M Dean,Olivia M Dean,Kristy Lu,Sue Jeavons,Ian Schapkaitz,Murray Anderson-Hunt,Fiona Judd,Fiona Katz,Paul Katz,Sean Ording-Jespersen,John Duncan Little,Philippe Conus,Michel Cuenod,Kim Q. Do,Ashley I. Bush,Ashley I. Bush,Ashley I. Bush +19 more
TL;DR: The data suggest that adjunctive NAC has potential as a safe and moderately effective augmentation strategy for chronic schizophrenia.
Journal ArticleDOI
Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate
TL;DR: Supernatants of brain macrophages in culture induce death of cerebellar granule cells in vitro, while those of astrocytes and endothelial cells do not, and might play a role in vivo in traumatic and cerebrovascular brain lesions.
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Perineuronal nets protect fast-spiking interneurons against oxidative stress
Jan-Harry Cabungcal,Pascal Steullet,Hirofumi Morishita,Rudolf Kraftsik,Michel Cuenod,Takao K. Hensch,Takao K. Hensch,Kim Q. Do +7 more
TL;DR: Using mice carrying a genetic redox imbalance, it is demonstrated that extracellular perineuronal nets, which constitute a specialized polyanionic matrix enwrapping most of these interneurons as they mature, play a critical role in the protection against oxidative stress.
Journal ArticleDOI
Redox dysregulation, neurodevelopment, and schizophrenia
TL;DR: In schizophrenia, a developmental redox dysregulation constitutes one 'hub' on which converge genetic impairments of glutathione synthesis and environmental vulnerability factors generating oxidative stress and novel interventions if applied in early phases of the disease hold great therapeutic promise.