Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

“Bioinformatics” 특집을 내면서

基礎講座 電気泳動(Electrophoresis)

Tables of integrals

Hypertension 66 (20.3%) 24 (24.2%) 30 (16.3%) NS Diabetes 20 (6.2%) 7 (7.1%) 10 (5.4%) NS Excess weight 78 (24%) 27 (27.3%) 44 (23.9%) NS Smokers 64 (19.7%) 17 (17.2%) 35 (19.0%) NS Age >50 years 137 (42.2%) 54 (54.5%) 67 (36.4%) <0.02 Kidney disease 7 (2.2%) 1 (1%) 5 (2.7%) NS Family history, DM 102 (31.4%) 28 (28.3%) 66 (35.9%) NS

Conflict of interest statement. None declared.

We investigate the statistical mechanics of a simple lattice model for the denaturation of the DNA double helix. The model consists of two chains connected by Morse potentials representing the H bonds. We determine the temperature dependence of the interstrand separation and we show that a mechanism involving an energy localization analogous to self-focusing may initiate the denaturation.

Statistical mechanics of a nonlinear model for DNA denaturation

List of Portraits Preface Part I. Different Classes of Solitons: Introduction 1. Nontopological solitons: the Korteweg-de Vries equation 2. Topological soltitons: sine-Gordon equation 3. Envelope solitons and nonlinear localisation: the nonlinear Schroedinger equation 4. The modelling process: ion acoustic waves in a plasma Part II. Mathematical Methods for the Study of Solitons: Introduction 5. Linearisation around the soliton solution 6. Collective coordinate method 7. The inverse-scattering transform Part III. Examples in Solid State and Atomic Physics: Introduction 8. The Ferm-Pasta-Ulam problem 9. A simple model for dislocations in crystals 10. Ferroelectric domain walls 11. Incommensurate phases 12. Solitons in magnetic systems 13. Solitons in Conducting polymers 14. Solitons in Bose-Einstein condensates Part IV. Nonlinear Excitations in Biological Molecules: Introduction 15. Energy localisation and transfer in proteins 16. Nonlinear dynamics and statistical physics of DNA Conclusion: Physical solitons: do they exist? Part V. Appendices: A. Derivation of the KdV equation for surface hydrodynamic waves B. Mechanics of a continuous medium C. Coherent states of an harmonic oscillator References Index.

Physics of solitons

We address the problem of heat conduction in 1D nonlinear chains; we show that, acting on the parameter which controls the strength of the on-site potential inside a segment of the chain, we induce a transition from conducting to insulating behavior in the whole system. Quite remarkably, the same transition can be observed by increasing the temperatures of the thermal baths at both ends of the chain by the same amount. The control of heat conduction by nonlinearity opens the possibility to propose new devices such as a thermal rectifier.

https://arxiv.org/pdf/cond-mat/0201125.pdf

Controlling the Energy Flow in Nonlinear Lattices: A Model for a Thermal Rectifier

DNA is not only an essential object of study for biologists—it also raises very interesting questions for physicists. This paper discuss its nonlinear dynamics, its statistical mechanics, and one of the experiments that one can now perform at the level of a single molecule and which leads to a non-equilibrium transition at the molecular scale.After a review of experimental facts about DNA, we introduce simple models of the molecule and show how they lead to nonlinear localization phenomena that could describe some of the experimental observations. In a second step we analyse the thermal denaturation of DNA, i.e. the separation of the two strands using standard statistical physics tools as well as an analysis based on the properties of a single nonlinear excitation of the model. The last part discusses the mechanical opening of the DNA double helix, performed in single molecule experiments. We show how transition state theory combined with the knowledge of the equilibrium statistical physics of the system can be used to analyse the results.

/pdf/nonlinear-dynamics-and-statistical-physics-of-dna-2c5ztjk1ut.pdf

Nonlinear dynamics and statistical physics of DNA

We present a nonlinear dynamical model for DNA denaturation which includes cooperativity effects through anharmonic nearest-neighbor stacking interactions. Transfer-integral calculations show that this one-dimensional model, without including long-range interactions, exhibits a sharp denaturation reminiscent of a first-order transition at a temperature lower than a similar model with harmonic coupling. Self-consistent phonon calculations point out the essential role of nonlinear effects in the mechanism.

Michel Peyrard

Papers

Statistical mechanics of a nonlinear model for DNA denaturation

Physics of solitons

Controlling the Energy Flow in Nonlinear Lattices: A Model for a Thermal Rectifier

Nonlinear dynamics and statistical physics of DNA

Entropy-driven DNA denaturation.