M
Michel Struys
Researcher at University Medical Center Groningen
Publications - 338
Citations - 12166
Michel Struys is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Propofol & Remifentanil. The author has an hindex of 55, co-authored 326 publications receiving 10268 citations. Previous affiliations of Michel Struys include Ghent University & University of Groningen.
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Journal ArticleDOI
Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine
Maud A S Weerink,Michel Struys,Michel Struys,Laura N. Hannivoort,Clemens R M Barends,Anthony Absalom,Pieter Colin,Pieter Colin +7 more
TL;DR: Dexmedetomidine as discussed by the authors is an α2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic, and analgesic-sparing effects, and minimal depression of respiratory function.
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Comparison of Closed-loop Controlled Administration of Propofol Using Bispectral Index as the Controlled Variable versus “Standard Practice” Controlled Administration
Michel Struys,Tom De Smet,Linda Versichelen,Stijn Van de Velde,Rudy Van den Broecke,Eric Mortier +5 more
TL;DR: A closed-loop system for propofol administration using the BIS as a controlled variable together with a model-based controller is clinically acceptable during general anesthesia.
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Depth of anaesthesia monitoring: what's available, what's validated and what's next?
TL;DR: Depth of anaesthesia monitors might help to individualize anaesthesia by permitting accurate drug administration against the measured state of arousal of the patient and the avoidance of awareness or excessive anaesthetic depth might result in improved patient outcomes.
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Pharmacokinetic models for propofol—defining and illuminating the devil in the detail
TL;DR: The recently introduced open-target-controlled infusion (TCI) systems can be programmed with any pharmacokinetic model, and allow either plasma- or effect-site targeting, and the Schnider model should always be used in effect- site targeting mode.
Journal ArticleDOI
Clinical Pharmacokinetics and Pharmacodynamics of Propofol.
TL;DR: An overview of the PK and PD of propofol is provided in order to refresh readers’ knowledge of its clinical applications, while discussing the main avenues of research where significant recent advances have been made.