Michela Biancolella

TL;DR: Analysis of the effect of the prevalent MAD mutation (R527H) over the transcriptional pattern of genes expressed in the human dermis showed that this LMNA gene mutation has pleiotropic effects on a limited number of genes.

TL;DR: To counteract NCDs, it is essential to develop an innovative, personalized, preventative, early care model through the integration of different molecular profiles of individuals to identify both the critical biomarkers of NCD susceptibility and to discover novel therapeutic targets.

TL;DR: A low-density home-made oligoarray containing 144 genes selected according to biochemical criteria was built and evaluated their expression in two CF bronchial epithelial cell lines, suggesting the identification of the genes altered by a specific CF mutation could lead to the development of a pharmacological approach specific for different CFTR genotypes

TL;DR: The present experiments were designed to characterize by microarray analysis the transcriptional responses of human keratinocytes to TNF-α and IL-1β, given alone or in combination, in order to better understand the mechanisms underlying inflammatory, immune responses and cell death in which both cytokines play a pathophysiological role.

TL;DR: Results show that identified mutations in this population are similar to those found in the east Mediterranean area, suggesting the same origin for mutant alleles during migratory streams.