M
Michele Azzolini
Researcher at University of Padua
Publications - 30
Citations - 931
Michele Azzolini is an academic researcher from University of Padua. The author has contributed to research in topics: Resveratrol & Prodrug. The author has an hindex of 16, co-authored 27 publications receiving 696 citations. Previous affiliations of Michele Azzolini include Karolinska Institutet.
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Journal ArticleDOI
Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo
Luigi Leanza,Matteo Romio,Katrin Anne Becker,Michele Azzolini,Livio Trentin,Antonella Managò,Elisa Venturini,Angela Zaccagnino,Andrea Mattarei,Luca Carraretto,Andrea Urbani,Stephanie Kadow,Lucia Biasutto,Veronica Martini,Filippo Severin,Roberta Peruzzo,Valentina Trimarco,Jan Hendrik Egberts,Charlotte Hauser,Andrea Visentin,Gianpietro Semenzato,Holger Kalthoff,Mario Zoratti,Erich Gulbins,Erich Gulbins,Cristina Paradisi,Ildikò Szabò +26 more
TL;DR: This work provides direct evidence that specific pharmacological targeting of a mitochondrial potassium channel can lead to ROS-mediated selective apoptosis of cancer cells in vivo, without causing significant side effects.
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The mitochondrial permeability transition pore in AD 2016: An update.
TL;DR: This review summarizes recent developments of research on the pathophysiological relevance and on the molecular nature of the mitochondrial permeability transition pore of Spastic Paraplegia 7, a mitochondrial AAA-type membrane protease which forms a 6-stave barrel.
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Acetal derivatives as prodrugs of resveratrol.
Andrea Mattarei,Michele Azzolini,Massimo Carraro,Nicola Sassi,Mario Zoratti,Cristina Paradisi,Lucia Biasutto +6 more
TL;DR: The results suggest that prodrugs of polyphenols based on the acetal bond and short ethyleneglycol oligomers of homogeneous size may be a convenient tool for the systemic delivery of the unconjugated parent compound.
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Pharmacokinetics and tissue distribution of pterostilbene in the rat.
Michele Azzolini,Martina La Spina,Andrea Mattarei,Cristina Paradisi,Mario Zoratti,Lucia Biasutto +5 more
TL;DR: Tissue distribution of Pt and its major metabolite, pterostilbene-4'-sulfate (Pt-S), in rats after oral administration is determined, finding a high fraction of nonmetabolized Pt in the brain, given the reports of its activity at the level of the central nervous system.
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The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain.
TL;DR: It is proposed that the effects of kynurenine pathway metabolites on skeletal muscle, adipose tissue, immune system, and the brain, suggest that some of these compounds could qualify as exercise-induced myokines.