M
Michele I. Saunders
Researcher at Mount Vernon Hospital
Publications - 101
Citations - 6621
Michele I. Saunders is an academic researcher from Mount Vernon Hospital. The author has contributed to research in topics: Radiation therapy & Carbogen. The author has an hindex of 43, co-authored 101 publications receiving 6448 citations.
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Journal ArticleDOI
Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: a randomised multicentre trial
TL;DR: CHART compared with conventional radiotherapy gave a significant improvement in survival of patients with NSCLC, and further improvement may be achieved with dose escalation in conformal radiotherapy, by the addition of cytotoxic chemotherapy, and by hypoxic cell radiosensitisation.
Journal ArticleDOI
Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial
Michele I. Saunders,Stanley Dische,Ann Barrett,Angela Harvey,Gareth Griffiths,Mahesh K. B. Parmar +5 more
TL;DR: This trial shows that control of local tumour can lead to an improvement in long term survival and demonstrates the importance of cellular repopulation as a cause of failure in the radiotherapy of NSCLC.
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A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer
Stanley Dische,Michele I. Saunders,Ann Barrett,Angela Harvey,Delia Gibson,Mahesh K. B. Parmar +5 more
TL;DR: Similar local turnout control was achieved by CHART as compared with conventional radiotherapy despite the reduction in total dose from 66 to 54 Gy supporting the importance of repopulation as a cause of radiation failure.
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Endogenous Markers of Two Separate Hypoxia Response Pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) Are Associated With Radiotherapy Failure in Head and Neck Cancer Patients Recruited in the CHART Randomized Trial
Michael I. Koukourakis,Søren M. Bentzen,Alexandra Giatromanolaki,George S. Wilson,Frances Daley,Michele I. Saunders,Stanley Dische,Efthimios Sivridis,Adrian L. Harris +8 more
TL;DR: Using immunohistochemical methods it is possible to identify subgroups of HNSCC patients who are highly curable with radiotherapy, or who are excellent candidates for clinical trials on hypoxia-targeting drugs in two distinct pathways.
Journal ArticleDOI
Epidermal Growth Factor Receptor Expression in Pretreatment Biopsies From Head and Neck Squamous Cell Carcinoma As a Predictive Factor for a Benefit From Accelerated Radiation Therapy in a Randomized Controlled Trial
Søren M. Bentzen,Beste M. Atasoy,Frances Daley,Stanley Dische,P I Richman,Michele I. Saunders,Klaus R. Trott,George S. Wilson +7 more
TL;DR: A key role for the EGFR receptor is indicated in determining the proliferative cellular response to fractionated radiotherapy in HNSCC and the dose-fractionation regime that has the greatest chance of benefiting the patient is selected.