Showing papers in "Radiotherapy and Oncology in 1999"

TL;DR: The global analysis of the Dutch study indicates the equality of a single fraction as compared to a 6 fraction treatment in patients with painful bone metastases provided that 4 times more retreatments are accepted in the single dose group.

TL;DR: Tumor oxygenation affects the prognosis of head and neck cancer independently of other known prognostic variables and this parameter may be a useful tool for the selection of patients for investigational treatment strategies.

TL;DR: This trial shows that control of local tumour can lead to an improvement in long term survival and demonstrates the importance of cellular repopulation as a cause of failure in the radiotherapy of NSCLC.

TL;DR: A single fraction of 8 Gy is as safe and effective as a multifraction regimen for the palliation of metastatic bone pain for at least 12 months, and the greater convenience and lower cost make 8 Gy single fraction the treatment of choice for the majority of patients.

TL;DR: Radiation therapy achieved excellent locoregional control of EMP with an approximate cure fraction of 50% and local control was achieved in 21 of 22 patients, and disease never recurred in regional nodes.

TL;DR: Prostatic displacement during a course of radiotherapy is more pronounced among patients with initial planning scans with large rectal and bladder volumes, and data indicate a tendency for the population towards posterior displacements of the prostate from the planning position and both posterior and superior displacement of the seminal vesicles.

TL;DR: The use of protons has been found to reduce the medium to low dose load to OARs and all non-target tissues compared to both standard and inversely planned photons, but that the use of intensity modulated photons can result in similar levels of high dose conformation to that afforded by protons.

TL;DR: This study confirms earlier data that the presence of hypoxia is associated with poor local control and survival in patients with carcinoma of the uterine cervix and Polarographic pO2 measurements are feasible under routine conditions and can be regarded as a reproducible predictive assay.

TL;DR: Systematic determination of the RBE values dependent upon the three interdependent variables identified in this manuscript will provide an enhanced data base for detailed treatment planning and institutional trial comparisons, thereby maximizing the therapeutic benefit of proton beams.

TL;DR: The m3 micro multi-leaf collimator is a stable, high precision field-shaping device suitable for small-field, radiosurgery applications and dose distributions can be accurately calculated by a planning system using only a few beam data parameters.

TL;DR: Assessment of the increased risk of secondary malignancies induced by Intensity modulated radiation therapy by means of in vivo measurements of the whole-body equivalent dose of both the conventional and the IMRT treatment techniques for head and neck lesions to assess whether the benefits of the treatment technique outweigh the possible risks.

TL;DR: This study quantifies the spatial distribution of pO2 in glioma and in the surrounding brain tissue and indicates that modalities targeting hypoxia to improve the efficacy of therapy may have an important role in the management of this disease.

TL;DR: Compared to patients in supine position, patients in prone position had smaller random but somewhat larger systematic variations in the most important coordinates of the internal CTV position, and the required planning margin is equal for both groups.

TL;DR: There may be more than one late (chronic) proctitis syndrome which may be linked in greater or lesser degrees to acuteProctitis symptoms occurring during therapy and the impact on normal daily life.

TL;DR: It appears that pretreatment cell kinetic measurements carried out using flow cytometry, only provide a relatively weak predictor of outcome after radiotherapy in head and neck cancer.

TL;DR: This study failed to show a significant survival advantage for any of the treatment arms or factors andHalving overall treatment time resulted in significantly greater oesophageal toxicity with no suggestion of a survival advantage.

TL;DR: Despite the use of an institutional contouring protocol, significant interclinician variations persist in contouring target volumes in NSCLC and additional measures to decrease such variations should be incorporated into clinical trials.

TL;DR: Disease free survival and subsequent development of distant metastases is reduced in the more than 60% of patients who respond to preoperative infusional chemoradiation, and evidence of response appears more significant than the degree of response.

TL;DR: The presence of individual patient susceptibility factors that determine the severity of acute mucosal reactions is suggested and a link between severe and prolonged acute reactions and the risk of developing late mucosal reacting that is independent of biological dose has been found.

TL;DR: Despite the moderate total dose and the low (mean) fraction dose to the heart, the observed incidence of ischemic heart disease is high, especially after long follow-up periods, which advocates a dose reduction to this level, particularly in the regions where the coronary arteries are located.

TL;DR: A full bladder is the prerequisite for an integral dose reduction in radiotherapy of gynaecological cancer and increased margins between CTV and PTV superiorly, inferiorly, anteriorly and posteriorly of 15, 6 and 9 mm each should be used.

TL;DR: Radiotherapy with total doses of < or =6 Gy has been given as very effective and low risk treatment of painful degenerative joint diseases and other inflammatory processes and mechanisms which may be related to these anti-inflammatory radiation effects are identified.

TL;DR: Three-dimensional tumour regrowth pattern relative to the treated volume shows that target-volumes based on the preoperative size of the enhanced tumour mass well cover the site of recurrence in nearly all cases and suggests dose escalation to a more restricted volume.

TL;DR: Calculations show that these repair halftimes are consistent with the observations from two published randomised controlled trials of altered fractionation in head and neck cancer, the EORTC 22791 and 22851 trials.

TL;DR: Axillary dissection obligates the radiotherapist to treat the axilla in order to include all tissues in the surgical bed, and should be avoided to reduce potential treatment related morbidity.

TL;DR: Rapid recovery of cytotoxic T-cells/natural killer cells after LRT and the functional suppression within normal levels explains the low incidence of infections after L RT.

TL;DR: 3D movement of a spherical liver tumor was detected using rapid MRI sequential examinations and magnetic resonance imaging has a potential to improve the accuracy of the planning target volume of a liver tumor.

TL;DR: Conave dose distributions generated by intensity modulated radiotherapy (IMRT) were applied to re-irradiate three patients with pharyngeal cancer to reduce the likelihood of relapsing or new tumors in the nasopharynx.

TL;DR: The 'simplified' protocol for the delineation of the 3D elective neck target produced both comparable target coverage and sparing of the major salivary glands and makes ENI with sparing ofThe major saliva glands a practical and achievable goal.

TL;DR: In 22 colostomy-free survivors of curative-intent radiation therapy or chemoradiation for anal carcinoma, measurement of the Gastrointestinal Quality of Life Index (GIQLI) revealed a mean 114 of a maximum 144 points, as compared to 121 in healthy volunteers and 113 in patients with benign anorectal diseases.