Michele M. Castro

TL;DR: Findings are consistent with the idea that antioxidants may help to prevent hypertension-induced cardiac hypertrophy and blunted the increases in TGF-β, the proteolytic imbalance, and the morphological and functional alterations found in 2K1C- induced cardiachypertrophy.

TL;DR: It is suggested that lercanidipine produces antihypertensive effects and reverses the endothelial dysfunction associated with 2K-1C hypertension, probably through mechanisms involving antioxidant effects leading to lower MMP-2 activation.

TL;DR: The results suggest that relatively lower doses of doxycycline do not attenuate the vascular alterations found in the rat two kidney‐one clip (2K1C) hypertension model, and only the highest dose of doXYcycline affects MMPs and vascular structure.

TL;DR: In vivo protective effect of the MMP inhibitor doxycycline against the development of vascular hyporeactivity in endotoxemic rats is demonstrated.

TL;DR: Quercetin reduces hypertension-induced vascular remodeling, oxidative stress and MMP-2 activity in aortas, and does not affect the levels of tissue inhibitor of MMP (TIMP)-2 and did not interfere with FAK and p-FAK levels in aorts of hypertensive rats.