M
Michele Minopoli
Researcher at Seconda Università degli Studi di Napoli
Publications - 24
Citations - 882
Michele Minopoli is an academic researcher from Seconda Università degli Studi di Napoli. The author has contributed to research in topics: Urokinase receptor & Cancer. The author has an hindex of 10, co-authored 17 publications receiving 375 citations.
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Journal ArticleDOI
Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy
TL;DR: In tumor patients, either a high number of TANs and Neutrophil-to-Lymphocyte Ratio (NLR) do correlate with poor prognosis, and, so far, TAN counts and NLR can be regarded as biomarkers.
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The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis.
TL;DR: This review will primarily focus on the pro-tumorigenic activity of NETs in tumors highlighting their ability to serve as a potential target for cancer therapy.
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Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation.
Chiara Ciardiello,Alessandra Leone,Paola Lanuti,María Roca,Tania Moccia,Valentina R. Minciacchi,Michele Minopoli,Vincenzo Gigantino,Rossella De Cecio,Massimo Rippa,Lucia Petti,Francesca Capone,Carlo Vitagliano,Maria Rita Milone,Biagio Pucci,Rita Lombardi,Federica Iannelli,Elena Di Gennaro,Francesca Bruzzese,Marco Marchisio,Maria Vincenza Carriero,Dolores Di Vizio,Alfredo Budillon +22 more
TL;DR: This study is the first to demonstrate the critical role of αV-integrin positive LO in PCa aggressive features, adding new insights in biological function of these large EVs and suggesting their potential use as PCa prognostic markers.
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Role of Microenvironment on the Fate of Disseminating Cancer Stem Cells.
Vincenzo Ingangi,Michele Minopoli,Concetta Ragone,Maria Letizia Motti,Maria Vincenza Carriero +4 more
TL;DR: This review will focus on specific CSC features with an emphasis on the role of tumor microenvironment in supporting metastatic dissemination of CSCs, and sheds light on potential microenvironment-targeted therapies aimed to counteract seeding and survival of C SCs in the metastatic niche.
Journal ArticleDOI
UPARANT: A Urokinase Receptor–Derived Peptide Inhibitor of VEGF-Driven Angiogenesis with Enhanced Stability and In Vitro and In Vivo Potency
Maria Vincenza Carriero,Katia Bifulco,Michele Minopoli,Luca Lista,Ornella Maglio,Luigi Mele,Gioconda Di Carluccio,Mario De Rosa,Vincenzo Pavone +8 more
TL;DR: Both excellent stability and potency position UPARANT as a promising new therapeutic agent for the control of diseases fueled by excessive angiogenesis, such as cancer and inflammation.