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Michèle Ourévitch

Researcher at Centre national de la recherche scientifique

Publications -  46
Citations -  935

Michèle Ourévitch is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Trifluoromethyl & Allylic rearrangement. The author has an hindex of 16, co-authored 46 publications receiving 855 citations. Previous affiliations of Michèle Ourévitch include Institute of Tropical Medicine Antwerp.

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Fluoro-artemisinins: When a gem-difluoroethylene replaces a carbonyl group

TL;DR: In this article, an alternative reaction involving the generation of an α-CF 3 carbanion, from the corresponding bromide 6, allowed the access to the target compound 8, and could also be exemplified in sugar series.
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Chemical modification of chitosan by glycidyl trimethylammonium chloride. Characterization of modified chitosan by 13C- and 1H-NMR spectroscopy

TL;DR: In this paper, a modified chitosan is discussed using elemental analysis and NMR spectroscopies, and the results are consistent with N-monoalkylation.
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Perfluorooctyl Bromide Polymeric Capsules as Dual Contrast Agents for Ultrasonography and Magnetic Resonance Imaging

TL;DR: Results show initial feasibility for development of these capsules toward a dual‐modality contrast agent and injections of nanocapsules in mice in vivo reveal that the initial bolus passage presents significant ultrasound enhancement of the blood pool during hepatic imaging.
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Trifluoromethylalkenes in cycloaddition reactions

TL;DR: In this paper, the influence of CF3-group on both the activation of the double bond and the stereochemistry of the cycloaddition has been evaluated, and new CF3substituted mono-and polycyclic compounds 4 and 7, highly functionalized isoxazolidines 18, 19, 22 and 23 and pyrrolidines 12, 13 and 16 have been prepared.
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Orally Active Antimalarials: Hydrolytically Stable Derivatives of 10-Trifluoromethyl Anhydrodihydroartemisinin†

TL;DR: New fluoroart Artemisinin derivatives containing polar or water-soluble functionalities at C-16 (11a-j, 12a-g) were synthesized using the key intermediate 16-bromo-10-trifluoromethyl anhydrodihydroartemisinin 10, and among them, amines 11a-c appeared to be highly in vivo efficient antimalarials on mice infected with Plasmodium berghei.