Michelle Alexander

TL;DR: In this article, the authors examined published clinical studies from the past 20 years where long-term IQ outcome scores for matched groups of male and female premature infants were reported separately (IQ being the most common outcome measure).

TL;DR: Behavioral deficits following neonatal HI are task-specific depending on timing of injury; the more pervasive behavioral deficits seen following P7 HI injury were associated with substantial global tissue loss; and persistent deficits in attention in P3 HI subjects might be linked to neural connectivity disturbances rather than a global loss of brain volume.

TL;DR: Results support sex differences in mechanisms of cell death following early HI injuries, and suggest a potential clinical benefit from the development of sex-specific neuroprotectants for the treatment of HI.

TL;DR: Investigating the therapeutic benefit of caffeine following early HI injury in male rats suggests that caffeine is a potential therapeutic agent that could be used in HI injured infants to reduce brain injury and preserve subsequent cognitive function.

TL;DR: The current data show that the effectiveness of a single dose of Epo in ameliorating auditory processing deficits following HI injury decreases precipitously as treatment is delayed following injury, which may have important implications for experimental human neonatal intervention with Epo.