M
Michelle E. Armstrong
Researcher at Trinity College, Dublin
Publications - 25
Citations - 1226
Michelle E. Armstrong is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 13, co-authored 22 publications receiving 1068 citations. Previous affiliations of Michelle E. Armstrong include Our Lady's Children's Hospital & Ulster University.
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Journal ArticleDOI
IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis
Emily Hams,Michelle E. Armstrong,Michelle E. Armstrong,Jillian L. Barlow,Sean P. Saunders,Sean P. Saunders,Christian Schwartz,Gordon Cooke,Ruairi J. Fahy,Thomas Crotty,Nikhil Hirani,Robin J. Flynn,David Voehringer,Andrew N. J. McKenzie,Seamas C. Donnelly,Padraic G. Fallon,Padraic G. Fallon +16 more
TL;DR: An innate mechanism for the generation of pulmonary fibrosis, via IL-25 and ILC2, that occurs independently of T-cell–mediated antigen-specific immune responses is presented, suggesting the potential of therapeutically targeting IL- 25 and I LC2 for the treatment of human fibrotic diseases.
Journal ArticleDOI
Cholera toxin promotes the induction of regulatory T cells specific for bystander antigens by modulating dendritic cell activation.
Ed C. Lavelle,Edel A. McNeela,Michelle E. Armstrong,Olive Leavy,Sarah C. Higgins,Kingston H. G. Mills +5 more
TL;DR: It is demonstrated that cholera toxin promotes the generation of regulatory T (Tr) cells against bystander Ag and induces maturation of DC, but, by inducing IL-10, inhibiting IL-12, and selectively affecting surface marker expression, suppresses thegeneration of Th1 cells and promotes the induction of T cells with regulatory activity.
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The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis.
David N O'Dwyer,Michelle E. Armstrong,Glenda Trujillo,Gordon Cooke,Michael P. Keane,Padraic G. Fallon,AJ Simpson,Ann B. Millar,Emmet E. McGrath,Moira K. B. Whyte,Nik Hirani,Cory M. Hogaboam,Seamas C. Donnelly +12 more
TL;DR: This study reveals the crucial role of defective TLR3 function in promoting progressive IPF and demonstrates increased collagen and profibrotic cytokines inTLR3 knockout mice (tlr3(-/-)) compared with wild-type mice ( tlr3(+/+).
Journal ArticleDOI
Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent
Ed C. Lavelle,Andrew G. Jarnicki,Edel A. McNeela,Michelle E. Armstrong,Sarah C. Higgins,Olive Leavy,Kingston H. G. Mills +6 more
TL;DR: It is shown that CT synergizes with LPS to induce IL‐6 and IL‐1β in addition to IL‐10 production by immature DC following exposure to CT, which may promote the induction of Th2 and Tr1 cells in part via selective modulation of DC cytokine production and costimulatory molecule expression.
Journal ArticleDOI
Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD).
David N O'Dwyer,Michelle E. Armstrong,Gordon Cooke,Jonathan D. Dodd,Douglas J. Veale,Seamas C. Donnelly +5 more
TL;DR: RA-ILD focused research offers the opportunity to identify early asymptomatic disease and define the natural history of this extra articular manifestation, which may provide a unique opportunity to define key regulatory fibrotic events driving progressive disease.