M
Moira K. B. Whyte
Researcher at University of Edinburgh
Publications - 89
Citations - 3674
Moira K. B. Whyte is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Inflammation & Idiopathic pulmonary fibrosis. The author has an hindex of 32, co-authored 85 publications receiving 2839 citations. Previous affiliations of Moira K. B. Whyte include Medical Research Council & University of Sheffield.
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Journal ArticleDOI
Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model
Philip M. Elks,Fredericus J.M. van Eeden,Giles Dixon,Xingang Wang,Constantino Carlos Reyes-Aldasoro,Philip W. Ingham,Moira K. B. Whyte,Sarah R. Walmsley,Stephen A. Renshaw +8 more
TL;DR: It is demonstrated that Hif-1α regulates neutrophil function in complex ways during inflammation resolution in vivo, and site-directed mutagenesis of Hif in vivo reveals that hydroxylation of HIF-1 α by prolyl hydoxylases critically regulates the Hif pathway in zebrafish neutrophils.
Journal ArticleDOI
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Richard J. Allen,Joanne Porte,Rebecca Braybrooke,Carlos Flores,Tasha E. Fingerlin,Justin M. Oldham,Beatriz Guillen-Guio,Shwu-Fan Ma,Tsukasa Okamoto,Alison E. John,Ma'en Obeidat,Ivana V. Yang,Amanda P. Henry,Richard Hubbard,Vidya Navaratnam,Gauri Saini,Norma Thompson,Helen Booth,Simon P. Hart,Michael Hill,Nik Hirani,Toby M. Maher,Robin J. McAnulty,Ann B. Millar,Philip L. Molyneaux,Helen Parfrey,Doris M Rassl,Moira K. B. Whyte,William A. Fahy,Richard P. Marshall,Eunice Oballa,Yohan Bossé,David C. Nickle,Don D. Sin,Wim Timens,Nick Shrine,Ian Sayers,Ian P. Hall,Imre Noth,David A. Schwartz,Martin D. Tobin,Louise V. Wain,Louise V. Wain,R. Gisli Jenkins +43 more
TL;DR: The identification of AKAP13 as a susceptibility gene for IPF increases the prospect of successfully targeting RhoA pathway inhibitors in patients with IPF.
Journal ArticleDOI
Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish
Caroline Gray,Catherine A. Loynes,Moira K. B. Whyte,David C. Crossman,Stephen A. Renshaw,Timothy J. A. Chico +5 more
TL;DR: It is shown that macrophages were effectively ablated by addition of the prodrug metronidazole, with no effect on neutrophil number, and Tg(fms:GAL4.VP16)i186 provides a powerful tool for intravital imaging and functional manipulation of macrophage behaviour during inflammation.
Journal ArticleDOI
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.
Richard J. Allen,Beatriz Guillen-Guio,Justin M. Oldham,Shwu-Fan Ma,Amy Dressen,Megan L. Paynton,Luke M. Kraven,Ma'en Obeidat,Xuan Li,Michael Ng,Rebecca Braybrooke,Maria Molina-Molina,Maria Molina-Molina,Brian D. Hobbs,Rachel K. Putman,Phuwanat Sakornsakolpat,Helen Booth,William A. Fahy,Simon P. Hart,Michael Hill,Nik Hirani,Richard Hubbard,Robin J. McAnulty,Ann B. Millar,Vidyia Navaratnam,Eunice Oballa,Helen Parfrey,Gauri Saini,Moira K. B. Whyte,Yingze Zhang,Naftali Kaminski,Ayodeji Adegunsoye,Mary E. Strek,Margaret Neighbors,Xuting R. Sheng,Gunnar Gudmundsson,Vilmundur Gudnason,Hiroto Hatabu,David J. Lederer,Ani Manichaikul,John D. Newell,John D. Newell,George T. O'Connor,George T. O'Connor,Victor E. Ortega,Hanfei Xu,Tasha E. Fingerlin,Yohan Bossé,Ke Hao,Philippe Joubert,David C. Nickle,Don D. Sin,Wim Timens,Wim Timens,Dominic Furniss,Andrew P. Morris,Andrew P. Morris,Krina T. Zondervan,Ian P. Hall,Ian P. Hall,Ian Sayers,Ian Sayers,Martin D. Tobin,Martin D. Tobin,Toby M. Maher,Toby M. Maher,Michael H. Cho,Gary M. Hunninghake,David A. Schwartz,Brian L. Yaspan,Philip L. Molyneaux,Philip L. Molyneaux,Carlos Flores,Imre Noth,R. Gisli Jenkins,R. Gisli Jenkins,Louise V. Wain,Louise V. Wain +77 more
TL;DR: The observation that decreased DEPTOR expression associates with increased susceptibility to IPF supports recent studies demonstrating the importance of mTOR signaling in lung fibrosis, and new signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility.
Journal ArticleDOI
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
Sarah R. Walmsley,Edwin R. Chilvers,Alfred A.R. Thompson,Kathryn Vaughan,Helen M. Marriott,Lisa C. Parker,Gary Shaw,Selina Parmar,Martin F. Schneider,Ian Sabroe,David H. Dockrell,Marta Milo,Cormac T. Taylor,Randall S. Johnson,Christopher W. Pugh,Peter J. Ratcliffe,Patrick H. Maxwell,Peter Carmeliet,Moira K. B. Whyte +18 more
TL;DR: A novel function for PHD3 is believed to be a novel function in regulating neutrophil survival in hypoxia and may enable the development of new therapeutics for inflammatory disease.