M
Michelle Ierna
Researcher at University of Strathclyde
Publications - 8
Citations - 837
Michelle Ierna is an academic researcher from University of Strathclyde. The author has contributed to research in topics: Enteropathy & Trichinella spiralis. The author has an hindex of 8, co-authored 8 publications receiving 763 citations. Previous affiliations of Michelle Ierna include Strathclyde Institute of Pharmacy and Biomedical Sciences.
Papers
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Journal ArticleDOI
MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
Mariola Kurowska-Stolarska,Stefano Alivernini,Stefano Alivernini,LucyE. Ballantine,Darren L. Asquith,Neal L. Millar,Derek S. Gilchrist,James H. Reilly,Michelle Ierna,Alasdair R. Fraser,Bartosz Stolarski,Charles McSharry,Axel J. Hueber,Derek Baxter,John Hunter,Foo Y. Liew,Iain B. McInnes +16 more
TL;DR: It is reported here that miR-155 is up-regulated insynovial membrane and synovial fluid (SF) macrophages from patients with rheumatoid arthritis, and miR–deficient mice are resistant to collagen-induced arthritis, with profound suppression of antigen-specific Th17 cell and autoantibody responses and markedly reduced articular inflammation.
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Supplementation of diet with krill oil protects against experimental rheumatoid arthritis
TL;DR: The study suggests that krill oil may be a useful intervention strategy against the clinical and histopathological signs of inflammatory arthritis.
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The role of IL-4, IL-13 and IL-4Ralpha in the development of protective and pathological responses to Trichinella spiralis.
TL;DR: Differences in background genotype may be an important component in the development host protection and the development of intestinal pathology accompanying the loss of GI helminths.
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Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection.
TL;DR: It is suggested that MC-derived IL-4 and TNF may regulate the induction of protective Th2 responses and intestinal inflammation associated with the expulsion of T. spiralis.
Journal ArticleDOI
Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging
Hannah E. Scales,Michelle Ierna,Karen M. Smith,Kirsty Ross,Gordon R. Meiklejohn,Janet C. Patterson-Kane,Iain B. McInnes,James M. Brewer,Paul Garside,Pasquale Maffia +9 more
TL;DR: It is demonstrated that longitudinal non-invasive duplexed optical fluorescence imaging provides a simple assessment of arthritic disease activity within the joints of mice following the induction of CIA and may represent a powerful tool to monitor the efficacy of drug treatments in preclinical studies.