J
James M. Brewer
Researcher at University of Glasgow
Publications - 145
Citations - 7201
James M. Brewer is an academic researcher from University of Glasgow. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 42, co-authored 145 publications receiving 6475 citations. Previous affiliations of James M. Brewer include University of Strathclyde & Life Sciences Institute.
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Journal ArticleDOI
MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion
Christopher J. Oliphant,You Yi Hwang,Jennifer A. Walker,Maryam Salimi,See Heng Wong,James M. Brewer,Alexandros Englezakis,Jillian L. Barlow,Emily Hams,Seth T. Scanlon,Graham S. Ogg,Padraic G. Fallon,Padraic G. Fallon,Andrew N J McKenzie +13 more
TL;DR: During transition to adaptive T cell-mediated immunity, the ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production and identifies a previously unappreciated pathway in the regulation of type-2 immunity.
Journal ArticleDOI
Reversal of the TCR stop signal by CTLA-4.
Helga Schneider,Helga Schneider,Jos Downey,Andrew M. Smith,Bernd H. Zinselmeyer,Bernd H. Zinselmeyer,Catherine M. Rush,Catherine M. Rush,James M. Brewer,James M. Brewer,Bin Wei,Nancy Hogg,Paul Garside,Paul Garside,Christopher E. Rudd,Christopher E. Rudd +15 more
TL;DR: It is shown that CTLA-4 increases T cell motility and overrides the T cell receptor (TCR)–induced stop signal required for stable conjugate formation between T cells and antigen-presenting cells, which suggests a fundamentally different model of reverse stop signaling.
Journal Article
Aluminium Hydroxide Adjuvant Initiates Strong Antigen-Specific Th2 Responses in the Absence of IL-4- or IL-13-Mediated Signaling
James M. Brewer,Margaret Conacher,Christopher A. Hunter,Markus Mohrs,Frank Brombacher,James Alexander +5 more
TL;DR: It is concluded that alum adjuvants can induce IL-4 production and Th2 responses independently ofIL-4 or IL-13, negating the requirement for an early source of IL- 4 in the Th2 response induced by this adjuvant.
Journal ArticleDOI
In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to freund's complete adjuvant, but continues to induce T helper 2 cytokine production.
TL;DR: Although production of the Th2 cytokine IL‐5 was totally inhibited in IL‐4‐deficient mice inoculated with FCA/OVA, there was no significant difference inIL‐5 production between the two strains when alum was used as adjuvant.
Journal ArticleDOI
How) do aluminium adjuvants work
TL;DR: This review aims to examine recent developments in the understanding of the physicochemical and biological aspects of research into aluminium adjuvants and appears that these agents fail to fit within the current principles underlying activation of the immune response.