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Michelle K Chung
Researcher at Princeton University
Publications - 2
Citations - 520
Michelle K Chung is an academic researcher from Princeton University. The author has contributed to research in topics: Glutamine & Lipogenesis. The author has an hindex of 2, co-authored 2 publications receiving 413 citations.
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Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia.
Jing-Jing Fan,Jurre J. Kamphorst,Robin Mathew,Michelle K Chung,Eileen White,Eileen White,Tomer Shlomi,Joshua D. Rabinowitz +7 more
TL;DR: Glutamine‐driven oxidative phosphorylation is a major means of ATP production even in hypoxic cancer cells, and pharmacological inhibition of oxidativeosphorylation markedly reduces energy charge, and glutamine but not glucose removal markedly lowers oxygen uptake.
Journal ArticleDOI
Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate.
TL;DR: Investigating quantitatively, using 13C-tracers and mass spectrometry, the sources of acetyl-CoA in hypoxia revealed that neither amino acids nor fatty acids are the primary source, and the main additional source is acetate.