T
Tomer Shlomi
Researcher at Technion – Israel Institute of Technology
Publications - 75
Citations - 9864
Tomer Shlomi is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Metabolic network & Flux (metabolism). The author has an hindex of 40, co-authored 72 publications receiving 8562 citations. Previous affiliations of Tomer Shlomi include University of California, San Diego & Tel Aviv University.
Papers
More filters
Journal ArticleDOI
Quantitative flux analysis reveals folate-dependent NADPH production
Jing-Jing Fan,Jiangbin Ye,Jurre J. Kamphorst,Tomer Shlomi,Craig B. Thompson,Joshua D. Rabinowitz +5 more
TL;DR: The ability to directly track, by liquid chromatography–mass spectrometry, the passage of deuterium from labelled substrates into NADPH, and combine this approach with carbon labelling and mathematical modelling to measure NADPH fluxes is demonstrated.
Journal ArticleDOI
Associating Genes and Protein Complexes with Disease via Network Propagation
TL;DR: A global, network-based method for prioritizing disease genes and inferring protein complex associations, which is called PRINCE, and applies to study three multi-factorial diseases for which some causal genes have been found already: prostate cancer, alzheimer and type 2 diabetes mellitus.
Journal ArticleDOI
Network-based prediction of human tissue-specific metabolism
TL;DR: This work presents a computational method that successfully describes the tissue specificity of human metabolism on a large scale by integrating tissue-specific gene- and protein-expression data with an existing comprehensive reconstruction of the global human metabolic network.
Journal ArticleDOI
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
Joanna Kaplon,Liang Zheng,Katrin Meissl,Barbara Chaneton,Vitaly A. Selivanov,Gillian M. Mackay,Sjoerd H. van der Burg,Elizabeth M. E. Verdegaal,Marta Cascante,Tomer Shlomi,Tomer Shlomi,Eyal Gottlieb,Daniel S. Peeper +12 more
TL;DR: It is shown that the mitochondrial gatekeeper pyruvate dehydrogenase (PDH) is a crucial mediator of senescence induced by BRAFV600E, an oncogene commonly mutated in melanoma and other cancers, and a mechanistic relationship between OIS and a key metabolic signalling axis is revealed, which may be exploited therapeutically.
Journal ArticleDOI
Regulatory on/off minimization of metabolic flux changes after genetic perturbations
TL;DR: ROOM is shown to accurately predict steady-state metabolic fluxes that maintain flux linearity, in agreement with experimental flux measurements, and to correctly identify short alternative pathways used for rerouting metabolic flux in response to gene knockouts.