Mieke Dolphens

TL;DR: A systematic review of structural and functional brain abnormalities in chronic low back pain (CLBP) using several brain magnetic resonance imaging (MRI) techniques is presented in this paper, where the authors evaluated structural gray matter changes.

TL;DR: An overview of the existing literature on the association of brain alterations with pain catastrophizing, fear‐avoidance, anxiety and depressive symptoms is provided, providing that even at rest the brain reserves a certain activity for these pain‐related factors.

TL;DR: A modern neuroscience approach, comprising therapeutic pain neuroscience education followed by cognition-targeted motor control training, is proposed, which explains why and how such an approach to CSP can be applied in physical therapist practice.

TL;DR: Results show a generalized increase in intramuscular fatty infiltration in lean muscle tissue in the absence of macroscopical signs of muscle degeneration after resolution of LBP, which might indicate a pathophysiological mechanism contributing to recurrence of L BP.

TL;DR: Central sensitization (CS) is defined as an amplification of neural signaling within the central nervous system that elicits pain hypersensitivity, increased responsiveness of nociceptive neurons to their normal or sub-threshold afferent input, or an augmentation of responsiveness of central neurons to input from unimodal and polymodal receptors as mentioned in this paper.