M
Mieke Snoek
Researcher at University of Amsterdam
Publications - 14
Citations - 1443
Mieke Snoek is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Interleukin 8 & Inflammation. The author has an hindex of 10, co-authored 14 publications receiving 1432 citations.
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Journal Article
Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients
Eddy A. Wierenga,Mieke Snoek,C.H. de Groot,I Chrétien,Jan D. Bos,Henk M. Jansen,Martien L. Kapsenberg +6 more
TL;DR: It is suggested that CD4+ T lymphocytes that produce IL-4, but not IFN-gamma, occur in high frequencies in the allergen-specific T cell repertoires of atopic donors, which may have important implications for the pathomechanism of atopy disease.
Journal Article
Human atopen-specific types 1 and 2 T helper cell clones
Eddy A. Wierenga,Mieke Snoek,Henk M. Jansen,Jan D. Bos,R. A. W. Van Lier,Martien L. Kapsenberg +5 more
TL;DR: The present data provide clear evidence for the existence of Th1 and Th2 cells in man and argue against a role for CD28 in this accessory helper function of the atopics' Th2 clones for IgE induction.
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Comparison of diversity and function of house dust mite-specific T lymphocyte clones from atopic and non-atopic donors
TL;DR: Observations do not give evidence for the occurrence of an abnormal Dp‐specific T cell repertoire in AD, but suggest aberrant secretion of the IgE‐inducing lymphokine IL 4 by CD4+ Dp-specific T cells from AD.
Journal ArticleDOI
Interleukin-17 Induces Hyperresponsive Interleukin-8 and Interleukin-6 Production to Tumor Necrosis Factor-α in Structural Lung Cells
Arjen van den Berg,Mathys Kuiper,Mieke Snoek,Wim Timens,Dirkje S. Postma,Henk M. Jansen,René Lutter +6 more
TL;DR: It is shown that by releasing IL-17 from memory T cells, the adaptive immune system instructs lung structural cells as part of the innate immune system to respond more vigorously to secondary stimuli, and is only a weak proinflammatory stimulus by itself.
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IFN-gamma amplifies IL-6 and IL-8 responses by airway epithelial-like cells via indoleamine 2,3-dioxygenase.
TL;DR: Whether and, if so, how IFN-γ can modulate proinflammatory responses to TNF-α and LPS by epithelial cells, which are key effector cells in the airways, is sought.