W
Wim Timens
Researcher at University Medical Center Groningen
Publications - 531
Citations - 32974
Wim Timens is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: COPD & Asthma. The author has an hindex of 77, co-authored 499 publications receiving 27572 citations. Previous affiliations of Wim Timens include University of Groningen & Maastricht University Medical Centre.
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Journal ArticleDOI
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
TL;DR: ACE2 is abundantly present in humans in the epithelia of the lung and small intestine, which might provide possible routes of entry for the SARS‐CoV.
Journal ArticleDOI
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Martin Peifer,Lynnette Fernandez-Cuesta,Martin L. Sos,Julie George,Danila Seidel,Lawryn H. Kasper,Dennis Plenker,Frauke Leenders,Ruping Sun,Thomas Zander,Roopika Menon,Mirjam Koker,Ilona Dahmen,Christian Müller,Vincenzo Di Cerbo,Hans Ulrich Schildhaus,Janine Altmüller,Ingelore Baessmann,Christian Becker,Bram De Wilde,Jo Vandesompele,Diana Böhm,Sascha Ansén,Franziska Gabler,Ines Wilkening,Stefanie Heynck,Johannes M. Heuckmann,Xin Lu,Scott L. Carter,Kristian Cibulskis,Shantanu Banerji,Gad Getz,Kwon-Sik Park,Daniel Rauh,Christian Grütter,Matthias Fischer,Laura Pasqualucci,Gavin M. Wright,Zoe Wainer,Prudence A. Russell,Iver Petersen,Yuan Chen,Erich Stoelben,Corinna Ludwig,Philipp A. Schnabel,Hans Hoffmann,Thomas Muley,Michael Brockmann,Walburga Engel-Riedel,Lucia Anna Muscarella,Vito Michele Fazio,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Erik Thunnissen,Egber Smit,Daniëlle A M Heideman,Peter J.F. Snijders,Federico Cappuzzo,C. Ligorio,Stefania Damiani,John K. Field,Steinar Solberg,Odd Terje Brustugun,Marius Lund-Iversen,Jörg Sänger,Joachim H. Clement,Alex Soltermann,Holger Moch,Walter Weder,Benjamin Solomon,Jean-Charles Soria,Pierre Validire,Benjamin Besse,Elisabeth Brambilla,Christian Brambilla,Sylvie Lantuejoul,Philippe Lorimier,Peter M. Schneider,Michael Hallek,William Pao,Matthew Meyerson,Matthew Meyerson,Julien Sage,Jay Shendure,Robert Schneider,Robert Schneider,Reinhard Büttner,Jürgen Wolf,Peter Nürnberg,Sven Perner,Lukas C. Heukamp,Paul K. Brindle,Stefan A. Haas,Roman K. Thomas +94 more
TL;DR: This study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background.
Journal ArticleDOI
Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer
Jonathan Weiss,Martin L. Sos,Danila Seidel,Martin Peifer,Thomas Zander,Johannes M. Heuckmann,Roland T. Ullrich,Roopika Menon,Sebastian Maier,Alex Soltermann,Holger Moch,Patrick Wagener,Florian Fischer,Stefanie Heynck,Mirjam Koker,Jakob Schöttle,Frauke Leenders,Franziska Gabler,Ines Dabow,Silvia Querings,Lukas C. Heukamp,Hyatt Balke-Want,Sascha Ansén,Daniel Rauh,Ingelore Baessmann,Janine Altmüller,Zoe Wainer,Matthew Conron,Gavin M. Wright,Prudence A. Russell,Ben Solomon,Elisabeth Brambilla,Christian Brambilla,Philippe Lorimier,Steinar Sollberg,Odd Terje Brustugun,Walburga Engel-Riedel,Corinna Ludwig,Iver Petersen,Jörg Sänger,Joachim H. Clement,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Erik Thunnissen,Egbert F. Smit,Daniëlle A.M. Heideman,Federico Cappuzzo,C. Ligorio,Stefania Damiani,Michael Hallek,Rameen Beroukhim,William Pao,Bert Klebl,Matthias Baumann,Reinhard Buettner,Karen Ernestus,Erich Stoelben,Jürgen Wolf,Peter Nürnberg,Peter Nürnberg,Sven Perner,Roman K. Thomas +62 more
TL;DR: F focal FGFR1 amplification is common in squamous cell lung cancer and associated with tumor growth and survival, suggesting that FGFR inhibitors may be a viable therapeutic option in this cohort of patients.
Journal ArticleDOI
Management of lung nodules detected by volume CT scanning
Rob J. van Klaveren,Matthijs Oudkerk,Mathias Prokop,Ernst T. Scholten,Kristiaan Nackaerts,René M. Vernhout,Carola A. van Iersel,Karien A. M. van den Bergh,Susan van 't Westeinde,Carlijn M. van der Aalst,Erik Thunnissen,Dong Ming Xu,Ying Wang,Yingru Zhao,Hester A. Gietema,Bartjan de Hoop,Harry J.M. Groen,Geertruida H. de Bock,Peter M. A. van Ooijen,Carla Weenink,Johny Verschakelen,Jan-Willem J. Lammers,Wim Timens,Dik Willebrand,Aryan Vink,Willem P.Th.M. Mali,Harry J. de Koning +26 more
TL;DR: Among subjects at high risk for lung cancer who were screened in three rounds of CT scanning and in whom noncalcified pulmonary nodules were evaluated according to volume and volume-doubling time, the chances of finding lung cancer 1 and 2 years after a negative first-round test were 1 in 1000 and 3 in 1000, respectively.
Journal ArticleDOI
The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma
B Abraham,Josep M. Antó,Esther Barreiro,Ehd Bel,Giovanni Bonsignore,Jean Bousquet,J. Castellsagué,Pascal Chanez,Fabio Cibella,Giuseppina Cuttitta,B. Dahlén,SE Dahlen,N Drews,Ratko Djukanovic,Leonardo M. Fabbri,Gert Folkerts,Mina Gaga,Christina Gratziou,G Guerrera,S. T. Holgate,P H Howarth,Sebastian L. Johnston,F. Kanniess,Johan Kips,Huib A. M. Kerstjens,Maria Kumlin,H. Magnussen,Frans P. Nijkamp,N. Papageorgiou,Alberto Papi,Dirkje S. Postma,Romain Pauwels,K. F. Rabe,K Richter,AC Roldaan,Micaela Romagnoli,A. Roquet,C Sanjuas,NM Siafakas,Wim Timens,Nikolaos Tzanakis,Vachier,A. M. Vignola,Louise Watson,G Yourgioti,Enfumosa Study Grp +45 more
TL;DR: It is suggested that severe asthma might be a different form of asthma rather than an increase in asthma symptoms, and longitudinal studies and interventions are needed to define the mechanisms in severe asthma.