R
René Lutter
Researcher at University of Amsterdam
Publications - 242
Citations - 13498
René Lutter is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Asthma & Bronchoalveolar lavage. The author has an hindex of 51, co-authored 227 publications receiving 11660 citations. Previous affiliations of René Lutter include Academic Medical Center & Albanian Mobile Communications.
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Journal ArticleDOI
Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria.
TL;DR: The crystal structure of bovine mitochondrial F1-ATPase determined at 2.8 Å resolution supports a catalytic mechanism in intact ATP synthase in which the three catalytic subunits are in different states of the catalytic cycle at any instant.
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Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study.
Bernadette Schurink,Eva Roos,Teodora Radonic,Ellis Barbé,Catherine S. C. Bouman,Hans H. de Boer,Hans H. de Boer,Godelieve J. de Bree,Esther B. Bulle,Eleonora Aronica,Sandrine Florquin,Judith Fronczek,Judith Fronczek,Leo M. A. Heunks,Menno D. de Jong,Lihui Guo,Romy du Long,René Lutter,Pam C. G. Molenaar,E. Andra Neefjes-Borst,Hans W.M. Niessen,Carel J. M. van Noesel,Joris J T H Roelofs,Eric J. Snijder,Eline C. Soer,Joanne Verheij,Alexander P.J. Vlaar,Wim Vos,Nicole N. van der Wel,Allard C. van der Wal,Paul van der Valk,Marianna Bugiani +31 more
TL;DR: In patients with lethal CO VID-19, an extensive systemic inflammatory response was present, with a continued presence of neutrophils and NETs, which suggests a maladaptive immune response and substantiates the evidence for immunomodulation as a target in the treatment of severe COVID-19.
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External validation of blood eosinophils, FE NO and serum periostin as surrogates for sputum eosinophils in asthma
Ariane H. Wagener,S.B. de Nijs,René Lutter,Ana R. Sousa,Els J.M. Weersink,E.H.D. Bel,P. J. Sterk +6 more
TL;DR: In patients with mild to moderate asthma, as well as patients with more severe asthma, blood eos inophils had the highest accuracy in the identification of sputum eosinophilia in asthma.
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IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
Suzanne M. Bal,Jochem H. Bernink,Maho Nagasawa,Jelle Groot,Medya Shikhagaie,Kornel Golebski,Cornelis M. van Drunen,René Lutter,René E. Jonkers,Pleun Hombrink,Melanie Bruchard,Julien Villaudy,J. Marius Munneke,Wytske Fokkens,Jonas S. Erjefält,Hergen Spits,Xavier Romero Ros +16 more
TL;DR: It is proposed that IL-12 and IL-4 govern ILC2 functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation.
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IL-10 Is an Important Mediator of the Enhanced Susceptibility to Pneumococcal Pneumonia after Influenza Infection
Koenraad F. van der Sluijs,Leontine J. R. van Elden,Monique Nijhuis,Rob Schuurman,Jennie M. Pater,Sandrine Florquin,Michel Goldman,Henk M. Jansen,René Lutter,Tom van der Poll +9 more
TL;DR: In this article, the role of IL-10 in host defense against Streptococcus pneumoniae after recovery from influenza infection was evaluated in a mouse model to study post-influenza pneumococcal pneumonia.