M
Miguel A. Rocha
Researcher at Veterans Health Administration
Publications - 9
Citations - 227
Miguel A. Rocha is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: RNA & Ribosomal RNA. The author has an hindex of 5, co-authored 8 publications receiving 212 citations. Previous affiliations of Miguel A. Rocha include University of California, Los Angeles.
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Journal ArticleDOI
Staphylococcus aureus Panton-Valentine Leukocidin Contributes to Inflammation and Muscle Tissue Injury
Ching Wen Tseng,Ching Wen Tseng,Pierre Kyme,Pierre Kyme,Jennifer E Low,Jennifer E Low,Miguel A. Rocha,Miguel A. Rocha,Randa Alsabeh,Loren G. Miller,Michael Otto,Moshe Arditi,Moshe Arditi,Binh An Diep,Victor Nizet,Terence M. Doherty,Terence M. Doherty,David O. Beenhouwer,David O. Beenhouwer,George Y. Liu,George Y. Liu +20 more
TL;DR: In a model of necrotizing soft tissue infection, PVL caused significant damage of muscle but not the skin, and the toxin could mediate tissue injury by mechanisms other than direct killing of phagocytes.
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Human Immunoglobulin G2 (IgG2) and IgG4, but Not IgG1 or IgG3, Protect Mice against Cryptococcus neoformans Infection
David O. Beenhouwer,David O. Beenhouwer,Esther M. Yoo,Chun-Wei Lai,Miguel A. Rocha,Sherie L. Morrison +5 more
TL;DR: The efficacies of anti-GXM MAbs of the four human immunoglobulin G (IgG) subclasses, which have identical variable regions but differ in their capacities to bind the three types of Fc receptors for IgG, their abilities to activate complement, and their half-lives are examined.
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Detection and quantification of Panton-Valentine leukocidin in Staphylococcus aureus cultures by ELISA and Western blotting: diethylpyrocarbonate inhibits binding of protein A to IgG.
Hien M. Nguyen,Miguel A. Rocha,Koteswara R. Chintalacharuvu,David O. Beenhouwer,David O. Beenhouwer +4 more
TL;DR: It is shown that the addition of diethylpyrocarbonate (DEPC) inhibits the binding of Spa to rabbit anti-PVL used as the capturing antibody in ELISA and in Western blotting, which should prove useful for detecting and quantifying proteins in S. aureus culture supernatants.
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Separately or combined, LukG/LukH is functionally unique compared to other staphylococcal bicomponent leukotoxins.
Machi Yanai,Miguel A. Rocha,Anthony Z. Matolek,Archana Chintalacharuvu,Yasuhiko Taira,Koteswara R. Chintalacharuvu,David O. Beenhouwer +6 more
TL;DR: The results showed that LukGH was more cytotoxic to human PMNs than PVL, however, LukGH-induced calcium ion influx in PMNs was markedly attenuated and slower than that induced by PVL and other staphylococcal BCLs.
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Nutrient depletion and TOR inhibition induce 18S and 25S ribosomal RNAs resistant to a 5'-phosphate-dependent exonuclease in Candida albicans and other yeasts.
TL;DR: Digestion of RNA by Terminator has revealed 18S and 25S rRNA molecules different from the accepted processed ones seen in ribosome generation, which suggests a useful biological role for it, worthy of further inquiry.