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George Y. Liu
Researcher at University of California, San Diego
Publications - 93
Citations - 7262
George Y. Liu is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Staphylococcus aureus & Innate immune system. The author has an hindex of 38, co-authored 87 publications receiving 6501 citations. Previous affiliations of George Y. Liu include University of Bristol & University of California, Los Angeles.
Papers
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Journal ArticleDOI
DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps.
John T. Buchanan,Amelia J. Simpson,Ramy K. Aziz,George Y. Liu,Sascha A. Kristian,Malak Kotb,James R. Feramisco,Victor Nizet +7 more
TL;DR: A significant role for NETs in neutrophil-mediated innate immunity is demonstrated, and a novel therapeutic target against invasive GAS infection is identified.
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IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
TL;DR: A new role for IKKα is described in the negative regulation of macrophage activation and inflammation, and the two IKK catalytic subunits have evolved opposing but complimentary roles needed for the intricate control of inflammation and innate immunity.
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Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity
George Y. Liu,Anthony Essex,John T. Buchanan,Vivekanand Datta,Hal M. Hoffman,Hal M. Hoffman,John F. Bastian,Joshua Fierer,Joshua Fierer,Victor Nizet,Victor Nizet +10 more
TL;DR: In this paper, the role of carotenoid pigments in virulence of Staphylococcus aureus was demonstrated, showing that blocking carotensynthesis increases oxidant sensitivity and decreases whole-blood survival, suggesting a novel target for antibiotic therapy.
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Low avidity recognition of self-antigen by T cells permits escape from central tolerance
George Y. Liu,Paul J. Fairchild,Richard M. Smith,John R. Prowle,Dimitris Kioussis,David C. Wraith +5 more
TL;DR: This work has addressed the hypothesis that the avidity of T cell recognition in the thymus may be compromised, enabling autoreactive T cells to escape self-tolerance by constructing transgenic mice expressing an encephalitogenic T cell receptor (TCR) by using analogs of intermediate affinity.
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A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence
Chia I. Liu,Chia I. Liu,George Y. Liu,Yongcheng Song,Fenglin Yin,Mary E. Hensler,Wen Yih Jeng,Victor Nizet,Andrew H.-J. Wang,Andrew H.-J. Wang,Eric Oldfield +10 more
TL;DR: The crystal structures of S. aureus dehydrosqualene synthase are determined and this finding represents proof of principle for a virulence factor–based therapy against S.Aureus, resulting in colorless bacteria with increased susceptibility to killing by human blood and to innate immune clearance in a mouse infection model.