Miguel T. Suderman

TL;DR: Compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype.

TL;DR: It is proposed that the variation in nucleotide sequence in the 3'NCR may have evolved as a function of DEN virus transmission and replication in different mosquito and non-human primate/human host cycles and the hypothesis that DEN viruses arose from sylvatic progenitors and evolved into human epidemic strains is consistent.

TL;DR: Antisera raised against a candidate Japanese encephalitis virus (JEV) vaccine, ChimeriVax-JE, and the currently licensed vaccine, JE-VAX, to protect against strains of JEV representing the four major genotypes was assessed.

TL;DR: Jatobal (JAT) virus was attenuated in hamsters compared to ORO virus suggesting that the S RNA ofORO virus is not directly involved in hamster virulence, and it is suggested that JAT virus is a reassortant containing the SRNA of OROirus.

TL;DR: Nucleotide sequencing revealed a high degree of homology between DTV and POW at both nucleotide and amino acid levels, and the two viruses were indistinguishable in serological assays and mouse neuroinvasiveness.