Eryu Wang

TL;DR: Endemic/epidemic dengue viruses (DEN) that are transmitted among humans by the mosquito vectors Aedes aegypti and Aedes albopictus are hypothesized to have evolved from sylvatic DEN strains that are transmission among nonhuman primates in West Africa and Malaysia by other Aedes mosquitoes.

TL;DR: Chikungunya virus is an emerging alphavirus that has caused major epidemics in India and islands off the east coast of Africa since 2005 and importations into Europe and the Americas underscore the risk of endemic establishment elsewhere.

TL;DR: It is proposed that RNA viruses can adapt to use antiviral properties of vertebrate miRNAs to limit replication in particular cell types and that this restriction can lead to exacerbation of disease severity.

TL;DR: Testing in both normal outbred and interferon response-defective mice indicated that the new vaccine candidate is highly attenuated, immunogenic and efficacious after a single dose, and incapable of replicating in mosquito cells or infecting mosquitoes in vivo.

TL;DR: Phylogenetic studies indicate that this isolate, the first from Mexico, is related to strains from the central United States but has a relatively high degree of sequence divergence.