Mikael Holma

TL;DR: P2RX7 and its risk alleles predisposed to mood disorders consistently in three independent clinical cohorts resulted in clinically significant differences in outcome of patients with major depressive and bipolar disorder.

TL;DR: In this article, the authors show that in sufficiently long (5 and 15-year) clinical and general-population follow ups, increases can be observed in the Temperament and Character Inventory's personality trait harm avoidance as a function of temporally accumulating major depressive episodes (132 depression patients from Vantaa Depression Study) and depressive symptoms (3105 participants from Young Finns general population sample).

TL;DR: Only BPI patients had an increased risk for deep WMHs, and DWMHs were independently associated with deficits in visual attention.

TL;DR: Among mood disorder patients, suicide attempt risk is associated with temperament and character dimensions, however, their influence on predisposition to suicide attempts is likely to be mainly indirect, mediated by more time spent in depressive episodes.

TL;DR: Among mood disorder patients, comorbid PDs increase the risk of SAs to approximately two-fold, and risk appears highest for PDs that most predispose to chronicity and recurrences.