M
Mikhalina Cortes
Researcher at Mental Health Research Institute
Publications - 5
Citations - 1100
Mikhalina Cortes is an academic researcher from Mental Health Research Institute. The author has contributed to research in topics: GSK-3 & Cognitive decline. The author has an hindex of 5, co-authored 5 publications receiving 1031 citations. Previous affiliations of Mikhalina Cortes include Florey Institute of Neuroscience and Mental Health.
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Journal ArticleDOI
Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ
Paul A. Adlard,Robert A. Cherny,Robert A. Cherny,David Finkelstein,David Finkelstein,Elisabeth Gautier,Elysia Robb,Mikhalina Cortes,Irene Volitakis,Xiang Liu,Jeffrey P. Smith,Keyla Perez,Keyla Perez,Katrina M. Laughton,Katrina M. Laughton,Qiao-Xin Li,Qiao-Xin Li,Susan A. Charman,Joseph A. Nicolazzo,Simon Wilkins,Simon Wilkins,Karolina Deleva,Toni Lynch,Gaik Beng Kok,Craig W. Ritchie,Rudolph E. Tanzi,Roberto Cappai,Roberto Cappai,Colin L. Masters,Colin L. Masters,Kevin J. Barnham,Kevin J. Barnham,Ashley I. Bush,Ashley I. Bush +33 more
TL;DR: The current data demonstrate that ionophore activity, inhibition of in vitro metal-mediated Abeta reactions, and blood-brain barrier permeability are indices that predict a potential disease-modifying drug for AD.
Journal ArticleDOI
Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
Peter J. Crouch,Lin Wai Hung,Paul A. Adlard,Mikhalina Cortes,Varsha Lal,Gulay Filiz,Keyla Perez,Milawaty Nurjono,Aphrodite Caragounis,Tai Du,Katrina M. Laughton,Irene Volitakis,Ashley I. Bush,Qiao-Xin Li,Colin L. Masters,Roberto Cappai,Robert A. Cherny,Paul S. Donnelly,Anthony R. White,Kevin J. Barnham +19 more
TL;DR: It is demonstrated that increasing intracellular copper bioavailability can restore cognitive function by inhibiting the accumulation of neurotoxic Aβ trimers and phosphorylated tau.
Journal ArticleDOI
In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.
Michelle T. Fodero-Tavoletti,David Smith,Catriona McLean,Paul A. Adlard,Kevin J. Barnham,Lisa E. Foster,Laura Leone,Keyla Perez,Mikhalina Cortes,Janetta G. Culvenor,Qiao-Xin Li,Katrina M. Laughton,Christopher C. Rowe,Colin L. Masters,Roberto Cappai,Victor L. Villemagne +15 more
TL;DR: It is indicated that PIB retention observed within the cortical gray matter regions of DLB subjects in [11C]-PIB PET studies is largely attributable to PIB binding to Aβ plaques and not Lewy bodies.
Journal ArticleDOI
Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer’s Disease
Vijaya Kenche,Lin W. Hung,Lin W. Hung,Keyla Perez,Keyla Perez,Irene Volitakes,Guiseppe Ciccotosto,Jeffrey Kwok,Nicole Critch,Nikki Sherratt,Mikhalina Cortes,Varsha Lal,Colin L. Masters,Kazuma Murakami,Roberto Cappai,Paul A. Adlard,Kevin J. Barnham,Kevin J. Barnham +17 more
TL;DR: A different approach to the design of aggregation inhibitors of Ab is reported and it is demonstrated that this approach can modify Ab in vivo and new Pt complexes that are suitable for in vivo studies are identified.
Journal Article
Increasing Cu bioavailability inhibits A beta oligomers and tau phosphorylation
Peter J. Crouch,Lin Wai Hung,Paul A. Adlard,Mikhalina Cortes,Varsha Lal,Gulay Filiz,Keyla Perez,Milawaty Nurjono,Aphrodite Caragounis,Tai Du,Katrina M. Laughton,Irene Volitakis,Ashley I. Bush,Qiao-Xin Li,Colin L. Masters,Roberto Cappai,Robert A. Cherny,Paul S. Donnelly,Anthony R. White,Kevin J. Barnham +19 more
TL;DR: In this article, the use of copper-bis(thiosemicarbazonoto) complexes to increase intracellular copper bioavailability and inhibit GSK3beta through activation of an Akt signaling pathway was proposed.