J
Janetta G. Culvenor
Researcher at University of Melbourne
Publications - 57
Citations - 4549
Janetta G. Culvenor is an academic researcher from University of Melbourne. The author has contributed to research in topics: Presenilin & Alpha-synuclein. The author has an hindex of 36, co-authored 57 publications receiving 4278 citations. Previous affiliations of Janetta G. Culvenor include Florey Institute of Neuroscience and Mental Health & Merck & Co..
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Journal ArticleDOI
Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking.
Michael J. Petris,J. F. B. Mercer,Janetta G. Culvenor,Paul J. Lockhart,Paul A. Gleeson,James Camakaris +5 more
TL;DR: It is suggested that MNK continuously recycles between the Golgi and the plasma membrane and elevated copper shifts the steady‐state distribution from the Gol Gi to the plasma membranes, revealing a novel system of regulated protein trafficking which ultimately leads to the efflux of an essential yet potentially toxic ligand.
Journal ArticleDOI
Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
Roberto Cappai,Su-Ling Leck,Deborah J. Tew,Deborah J. Tew,Nicholas A. Williamson,David Smith,David Smith,Denise Galatis,Denise Galatis,Robyn A. Sharples,Cyril C. Curtain,Cyril C. Curtain,Feda E. Ali,Feda E. Ali,Robert A. Cherny,Robert A. Cherny,Janetta G. Culvenor,Janetta G. Culvenor,Stephen P. Bottomley,Colin L. Masters,Colin L. Masters,Kevin J. Barnham,Kevin J. Barnham,Andrew F. Hill +23 more
TL;DR: DA inhibited the formation of iron‐induced α‐SN amyloidogenic aggregates, suggesting that DA acts as a dominant modulator of α‐ SN aggregation, and support the paradigm emerging for other neurodegenerative diseases that the toxic species is represented by a soluble oligomer and not the insoluble fibril.
Journal ArticleDOI
The solubility of α‐synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
Bruce C.V. Campbell,Catriona McLean,Janetta G. Culvenor,Wei Ping Gai,Peter C. Blumbergs,Pekka Jäkälä,Konrad Beyreuther,Colin L. Masters,Qiao-Xin Li +8 more
TL;DR: There was an inverse correlation between buffered saline‐soluble and detergent‐ solubility levels of αSN in individual MSA cases suggesting a transition towards insolubility in disease, and it is therefore possible thatbuffered saline-soluble or detergent-insoluble forms of α SN are involved in the pathogenesis of other αSN‐related diseases.
Journal ArticleDOI
Selective inhibition of a two-step egress of malaria parasites from the host erythrocyte.
TL;DR: It is confirmed, with the use of immunoelectron microscopy, that parasitophorous vacuole membrane rupture occurs before erythrocyte plasma membrane rupture in untransfected wild-type parasites.
Journal ArticleDOI
Non-Aβ Component of Alzheimer's Disease Amyloid (NAC) Revisited: NAC and α-Synuclein Are Not Associated with Aβ Amyloid
Janetta G. Culvenor,Catriona McLean,Sally Cutt,Bruce C.V. Campbell,Fran Maher,Pekka Jäkälä,Tobias Hartmann,Konrad Beyreuther,Colin L. Masters,Qiao-Xin Li +9 more
TL;DR: In this article, the non-Aβ component of α-Synuclein (αSN) was identified as a constituent of AD amyloid plaques and α-SN was raised to three domains of αSN.