M
Mikko Salaspuro
Researcher at University of Helsinki
Publications - 228
Citations - 8732
Mikko Salaspuro is an academic researcher from University of Helsinki. The author has contributed to research in topics: Acetaldehyde & Ethanol. The author has an hindex of 53, co-authored 228 publications receiving 8313 citations. Previous affiliations of Mikko Salaspuro include Helsinki University Central Hospital.
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Journal ArticleDOI
Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer
Nils Homann,Jyrki Tillonen,Jukka H. Meurman,Hanna Rintamäki,Christian Lindqvist,Merja Rautio,Hannele Jousimies-Somer,Mikko Salaspuro +7 more
TL;DR: Increased local microbial salivary acetaldehyde production due to ethanol among smokers and heavy drinkers could be a biological explanation for the observed synergistic carcinogenic action of alcohol and smoking on upper gastrointestinal tract cancer.
Journal ArticleDOI
High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications.
TL;DR: It is concluded, that the microbial formation of acetaldehyde in saliva could be one explanation for the tumor promoting effect of ethanol on the upper gastrointestinal tract and this may support the epidemiological finding, that poor oral hygiene is an independent risk factor for oral cavity cancer.
Journal ArticleDOI
Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva
Ville Salaspuro,Mikko Salaspuro +1 more
TL;DR: It is concluded that this markedly increased exposure of upper digestive tract mucosa to carcinogenic salivary acetaldehyde of smoking and drinking subjects may explain the synergistic and multiplicative risk effect of alcohol drinking and tobacco smoking on upper gastrointestinal tract carcinogenesis.
Journal ArticleDOI
High Salivary Acetaldehyde After a Moderate Dose of Alcohol in ALDH2‐Deficient Subjects: Strong Evidence for the Local Carcinogenic Action of Acetaldehyde
TL;DR: Using this human "knockout model" for deficient acetaldehyde removal, it is found that in addition to oral microflora, acetaldehyde in saliva may also originate from the oxidation of ethanol in the parotid gland.
Journal ArticleDOI
Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers
Nils Homann,Jyrki Tillonen,Hanna Rintamäki,Mikko Salaspuro,Christian Lindqvist,Jukka H. Meurman +5 more
TL;DR: Poor dental status was shown to lead to an approximately twofold increase in salivary acetaldehyde production from ethanol (P=0.02), which could be an important factor underlying the role of poor dental hygiene and status in oral cancer risk associated with ethanol drinking.