M
Miklos Gaszner
Researcher at National Institutes of Health
Publications - 11
Citations - 3596
Miklos Gaszner is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Histone code & Chromatin. The author has an hindex of 11, co-authored 11 publications receiving 3474 citations. Previous affiliations of Miklos Gaszner include Princeton University & Laboratory of Molecular Biology.
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Journal ArticleDOI
Insulators: many functions, many mechanisms
TL;DR: Eukaryotic genomes are organized into domains containing individual genes and gene clusters that have distinct patterns of expression both during development and in differentiated cells.
Journal ArticleDOI
Insulators: exploiting transcriptional and epigenetic mechanisms
Miklos Gaszner,Gary Felsenfeld +1 more
TL;DR: New insights suggest that the mechanisms of action of both enhancer blockers and barriers might not be unique to these types of element, but instead are adaptations of other gene-regulatory mechanisms.
Journal ArticleDOI
Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus
TL;DR: A mechanism by which the insulator in the β-globin locus can protect the globin genes from being silenced by adjacent condensed chromatin is proposed.
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Position-effect protection and enhancer blocking by the chicken β-globin insulator are separable activities
Félix Recillas-Targa,Michael J. Pikaart,Bonnie Burgess-Beusse,Adam C. Bell,Michael D. Litt,Adam G. West,Miklos Gaszner,Gary Felsenfeld +7 more
TL;DR: It is shown here that a 250-bp “core” element from within 5′HS4 is sufficient to confer protection against silencing of transgenes caused by CPE, and compared with those of other CTCF-binding enhancer-blocking elements suggests that CPE protection is associated with maintenance of a high level of histone acetylation near the insulator.
Journal ArticleDOI
The insulation of genes from external enhancers and silencing chromatin
Bonnie Burgess-Beusse,Catherine M. Farrell,Miklos Gaszner,Michael D. Litt,Vesco Mutskov,Félix Recillas-Targa,Melanie A. Simpson,Adam G. West,Gary Felsenfeld +8 more
TL;DR: DNA sequence elements that can serve in some cases as barriers to protect a gene against the encroachment of adjacent inactive condensed chromatin also can act as blocking elements to protect against the activating influence of distal enhancers associated with other genes.