C
Catherine M. Farrell
Researcher at National Institutes of Health
Publications - 18
Citations - 7367
Catherine M. Farrell is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RefSeq & Gene. The author has an hindex of 15, co-authored 16 publications receiving 5808 citations. Previous affiliations of Catherine M. Farrell include University of California, Santa Cruz.
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Journal ArticleDOI
Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation
Nuala A. O'Leary,Mathew W. Wright,J. Rodney Brister,Stacy Ciufo,Diana Haddad,Richard McVeigh,Bhanu Rajput,Barbara Robbertse,Brian Smith-White,Danso Ako-adjei,Alexander Astashyn,Azat Badretdin,Yiming Bao,Olga Blinkova,Vyacheslav Brover,Vyacheslav Chetvernin,Jinna Choi,Eric Cox,Olga Ermolaeva,Catherine M. Farrell,Tamara Goldfarb,Tripti Gupta,Daniel H. Haft,Eneida L. Hatcher,Wratko Hlavina,Vinita Joardar,Vamsi K. Kodali,Wenjun Li,Donna Maglott,Patrick Masterson,Kelly M. McGarvey,Michael R. Murphy,Kathleen O'Neill,Shashikant Pujar,Sanjida H. Rangwala,Daniel Rausch,Lillian D. Riddick,Conrad L. Schoch,Andrei Shkeda,Susan S. Storz,Hanzhen Sun,Françoise Thibaud-Nissen,Igor Tolstoy,Raymond E. Tully,Anjana R. Vatsan,Craig Wallin,David Webb,Wendy Wu,Melissa J. Landrum,Avi Kimchi,Tatiana Tatusova,Michael DiCuccio,Paul Kitts,Terence Murphy,Kim D. Pruitt +54 more
TL;DR: The approach to utilizing available RNA-Seq and other data types in the authors' manual curation process for vertebrate, plant, and other species is summarized, and a new direction for prokaryotic genomes and protein name management is described.
Journal ArticleDOI
RefSeq: an update on mammalian reference sequences
Kim D. Pruitt,Garth Brown,Susan M. Hiatt,Françoise Thibaud-Nissen,Alexander Astashyn,Olga Ermolaeva,Catherine M. Farrell,Jennifer Hart,Melissa J. Landrum,Kelly M. McGarvey,Michael R. Murphy,Nuala A. O'Leary,Shashikant Pujar,Bhanu Rajput,Sanjida H. Rangwala,Lillian D. Riddick,Andrei Shkeda,Hanzhen Sun,Pamela Tamez,Raymond E. Tully,Craig Wallin,David Webb,Janet Weber,Wendy Wu,Michael DiCuccio,Paul Kitts,Donna Maglott,Terence Murphy,James Ostell +28 more
TL;DR: The National Center for Biotechnology Information (NCBI) Reference Sequence (RefSeq) database is a collection of annotated genomic, transcript and protein sequence records derived from data in public sequence archives and from computation, curation and collaboration.
Journal ArticleDOI
The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes
Kim D. Pruitt,Jennifer Harrow,Rachel A. Harte,Craig Wallin,Mark Diekhans,Donna Maglott,Steve Searle,Catherine M. Farrell,Jane E. Loveland,Barbara J. Ruef,Elizabeth M. Hart,Marie-Marthe Suner,Melissa J. Landrum,Bronwen Aken,Sarah Ayling,Robert Baertsch,Julio Fernandez-Banet,Joshua L. Cherry,Val Curwen,Michael DiCuccio,Manolis Kellis,Jennifer M. Lee,Michael F. Lin,Michael Schuster,Andrew Shkeda,Clara Amid,Garth Brown,Oksana Dukhanina,Adam Frankish,Jennifer Hart,Bonnie L. Maidak,Jonathan M. Mudge,Michael R. Murphy,Terence Murphy,Jeena Rajan,Bhanu Rajput,Lillian D. Riddick,Catherine E. Snow,Charles A. Steward,David Webb,Janet Weber,Laurens G. Wilming,Wenyu Wu,Ewan Birney,David Haussler,Tim Hubbard,James Ostell,Richard Durbin,David J. Lipman +48 more
TL;DR: The CCDS database centralizes the function of identifying well-supported, identically-annotated, protein-coding regions and indicates that the entries in the CCDS set are highly likely to represent real proteins, more so than annotations from contributing groups not included in CCDS.
Journal ArticleDOI
The insulation of genes from external enhancers and silencing chromatin
Bonnie Burgess-Beusse,Catherine M. Farrell,Miklos Gaszner,Michael D. Litt,Vesco Mutskov,Félix Recillas-Targa,Melanie A. Simpson,Adam G. West,Gary Felsenfeld +8 more
TL;DR: DNA sequence elements that can serve in some cases as barriers to protect a gene against the encroachment of adjacent inactive condensed chromatin also can act as blocking elements to protect against the activating influence of distal enhancers associated with other genes.
Journal ArticleDOI
Conserved CTCF Insulator Elements Flank the Mouse and Human β-Globin Loci
TL;DR: The data suggest that 3′HS1 and 5′HS5 may function as insulators that prevent inappropriate interactions between β-globin regulatory elements and those of neighboring domains or subdomains, many of which possess strong enhancers.