M
Miller Andrew T
Researcher at Novartis Foundation
Publications - 3
Citations - 155
Miller Andrew T is an academic researcher from Novartis Foundation. The author has contributed to research in topics: Adjuvant & Immunopharmacology. The author has an hindex of 1, co-authored 3 publications receiving 136 citations.
Papers
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Journal ArticleDOI
Rational design of small molecules as vaccine adjuvants
Tom Y.-H. Wu,Manmohan Singh,Miller Andrew T,Ennio De Gregorio,Francesco Doro,Ugo D'Oro,David A. G. Skibinski,M. Lamine Mbow,Simone Bufali,Ann E. Herman,Alex Cortez,Yongkai Li,Bishnu P. Nayak,Elaine Tritto,Christophe M. Filippi,Gillis R. Otten,Luis Brito,Elisabetta Monaci,Chun Li,Susanna Aprea,Sara Valentini,Samuele Calabrό,Donatello Laera,Brunella Brunelli,Elena Caproni,Padma Malyala,Rekha G. Panchal,Travis K. Warren,Sina Bavari,Derek T. O'Hagan,Michael P. Cooke,Nicholas Valiante +31 more
TL;DR: In vivo potency can be increased with little to no systemic exposure, localized innate immune activation and short in vivo residence times of SMIP-based adjuvants, and this work provides a systematic and generalizable approach to engineering small molecules for use as vaccine adjuvant.
Patent
Pyrimidine compounds containing acidic groups useful to treat diseases connected to the modulation of tlr7
TL;DR: In this paper, a class of pyrimidine derivatives of formula (I) having immunomodulating properties that act via TLR7 which are useful in the treatment of lung cancer and other respiratory conditions are discussed.
Patent
Compositions comprising naphthyridine derivatives and aluminium adjuvant for use in treating solid tumors
TL;DR: In this article, a TLR7 agonist having the structure of Formula (A), aluminum-containing particles, and one or more pharmaceutically acceptable excipient was provided for the treatment of solid tumors.