M
Minfeng Shu
Researcher at Fudan University
Publications - 26
Citations - 786
Minfeng Shu is an academic researcher from Fudan University. The author has contributed to research in topics: Glioma & Protein kinase A. The author has an hindex of 14, co-authored 23 publications receiving 640 citations. Previous affiliations of Minfeng Shu include International Institute of Minnesota & University of Chicago.
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Journal ArticleDOI
Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells
Minfeng Shu,Xiaoke Zheng,Sihan Wu,Huimin Lu,Tiandong Leng,Wenbo Zhu,Yuehan Zhou,Yanqiu Ou,Xi Lin,Yuan Lin,Dong Xu,Yuxi Zhou,Guangmei Yan +12 more
TL;DR: It is reported that microRNA-335 acts as a tumor promoter in conferring tumorigenic features such as growth and invasion on malignant astrocytoma and the oncogenic effects of miR-335 and siDAAM1 together with anti-tumor effects of antagomir-335 are confirmed in human astroCytoma U87-MG cells.
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MiR-135a functions as a selective killer of malignant glioma
Sihan Wu,Yuan Lin,Dong Xu,Jingkao Chen,Minfeng Shu,Yuwei Zhou,Wei-Guo Zhu,Xinwen Su,Pengxin Qiu,Guangmei Yan +9 more
TL;DR: Glia-enriched miR-135a, a microRNA that is dramatically downregulated in malignant glioma and correlated with the pathological grading, is capable of inducing mitochondria-dependent apoptosis of malignantglioma by regulating various genes including STAT6, SMAD5 and BMPR2, as well as affecting the signaling pathway downstream.
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A Small-Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma Cells via Down-Regulation of the Nuclear Factor-κB Pathway
Wenbo Zhu,Yanqiu Ou,Yan Li,Ru Xiao,Minfeng Shu,Yuehan Zhou,Jun Xie,Songmin He,Pengxin Qiu,Guangmei Yan +9 more
TL;DR: It is reported that triptolide, a small molecule from a Chinese herb, could potently inhibit proliferation in vitro, angiogenesis in vivo, and invasion in a Matrigel model in human ATC cell line TA-K cells at nanomolar concentrations.
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Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.
TL;DR: It is shown that another virion protein, UL47, brought into the cell during infection, attenuates the VHS-RNase activity with respect to stable host and viral α mRNAs and effectively blocks the degradation of β and γ mRNas, but it has no effect on the processing of AU-rich m RNAs.
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MicroRNA 335 Is Required for Differentiation of Malignant Glioma Cells Induced by Activation of cAMP/Protein Kinase A Pathway
TL;DR: It is demonstrated that microRNA 335 (miR-335) is responsible for the glioma cell differentiation stimulated by activation of cAMP/PKA pathway, and a single microRNA may act as an important fate determinant to control the differentiation status of malignant gliomas.