M
Ming Zhou
Researcher at Huazhong Agricultural University
Publications - 52
Citations - 831
Ming Zhou is an academic researcher from Huazhong Agricultural University. The author has contributed to research in topics: Rabies virus & Rabies. The author has an hindex of 12, co-authored 52 publications receiving 547 citations. Previous affiliations of Ming Zhou include University of Georgia.
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Enhancement of blood-brain barrier permeability and reduction of tight junction protein expression are modulated by chemokines/cytokines induced by rabies virus infection.
TL;DR: It was found that RABV infection enhances BBB permeability by downregulation of tight junction (TJ) protein expression in the brain microvasculature and blocking some of these cytokines, such as IFN-γ, ameliorated both the disruption of BBb permeability and the down regulation of TJ protein expression.
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A novel rabies vaccine based on a recombinant parainfluenza virus 5 expressing rabies virus glycoprotein
Zhenhai Chen,Ming Zhou,Xiudan Gao,Guoqing Zhang,Guiping Ren,Clement W. Gnanadurai,Zhen F. Fu,Zhen F. Fu,Biao He +8 more
TL;DR: Results indicate that rPIV5-RV-G is an excellent candidate for a new generation of recombinant rabies vaccine for humans and animals and PIV5 is a potential vector for oral vaccines.
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Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations.
Ming Zhou,Guoqing Zhang,Guiping Ren,Clement W. Gnanadurai,Zhenguang Li,Qingqing Chai,Yang Yang,Christina M. Leyson,Wenxue Wu,Min Cui,Zhen F. Fu,Zhen F. Fu +11 more
TL;DR: These studies suggest that recombinant RABV expressing GM-CSF or flagellin are more immunogenic than the parent virus in both i.m. and oral immunizations.
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Critical Role of K1685 and K1829 in the Large Protein of Rabies Virus in Viral Pathogenicity and Immune Evasion.
Dayong Tian,Zhaochen Luo,Ming Zhou,Mingming Li,Lan Yu,Chong Wang,Jiaolong Yuan,Fang Li,Bin Tian,Baokun Sui,Huanchun Chen,Zhen F. Fu,Ling Zhao +12 more
TL;DR: The results suggest that K1685 and K1829 in the L protein play important roles in pathogenicity and immune evasion during RABV infection.
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Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway
Bin Tian,Ming Zhou,Yu Yang,Lan Yu,Zhaochen Luo,Dayong Tian,Wang Ke,Min Cui,Huanchun Chen,Zhen F. Fu,Zhen F. Fu,Ling Zhao +11 more
TL;DR: It is demonstrated that lab-attenuated RABV causes abortive infection in astrocytes, the most abundant glial cells in the CNS, and it is suggested that astroCytes play a critical role in limiting the replication of lab-hatted RABVs in the central nervous system.