Mingfeng Xia

TL;DR: Animal experiments showed that BBR located favorably in the liver and altered hepatic metabolism-related gene expression in an animal model of NAFLD treated with BBR, suggesting that the therapeutic effect of BBR may involve a direct regulation of hepatic lipid metabolism.

TL;DR: Computer‐aided US is a valid method to estimate liver fat content and can be applied extensively after standardization of ultrasound quantitative parameters.

TL;DR: Berberine reduces liver TG synthesis and attenuates hepatic steatosis through the activation of AMPK-SREBP-1c-SCD1 pathway and sterol regulatory element (SRE) motif in SCD1 promoter was responsible for the BBR-induced suppression of SCD 1.

TL;DR: This work investigated the mechanisms by which berberine regulates hepatic lipid metabolism and energy expenditure in mice and found it to be a central regulator of energy expenditure.

TL;DR: Serum FGF21 was a potential biomarker to reflect the hepatic fat content in patients with mild or moderate NAFLD and within the range of hepatic steatosis from the first to third quartile, FGF 21 was superior to any other traditional clinical markers including ALT to reflect hepaticfat content.