MingMing Ning

TL;DR: Hemorrhages identified by MRI predict clinically important events in survivors of lobar ICH, and detection of microhemorrhage may be useful for assessing risk in ICH patients and as a surrogate marker for clinical studies.

TL;DR: By augmenting matrix metalloproteinase (MMP) dysregulation after stroke, tPA may degrade extracellular matrix integrity and increase risks of neurovascular cell death, blood–brain barrier leakage, edema, and hemorrhage.

TL;DR: The initial functional status at admission, rather than the stroke subgroup, better predicts discharge functional outcomes postrehabilitation, and patients with stroke made significant functional gains and should be offered rehabilitation regardless of stroke vascular territory.

TL;DR: In early human stroke, evidence of increased oxidative stress and a relationship with MMP-9 expression is found, supporting findings from experimental studies.

TL;DR: Tissue plasminogen activator independently predicted plasma matrix metalloproteinase-9 (MMP9) in the first 8 hours after human ischemic stroke as MMP9 may be an important mediator of hemorrhagic transformation, alternative thrombolytic agents or therapeutic M MP9 inhibition may increase the safety profile of acute stroke thromBOlysis.