E
Eng H. Lo
Researcher at Harvard University
Publications - 523
Citations - 38973
Eng H. Lo is an academic researcher from Harvard University. The author has contributed to research in topics: Stroke & Ischemia. The author has an hindex of 96, co-authored 495 publications receiving 34387 citations. Previous affiliations of Eng H. Lo include University of Toronto & Autonomous University of Barcelona.
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Mechanisms, challenges and opportunities in stroke
TL;DR: This new research focus addresses an important need in stroke research, provides challenges and opportunities that can be used to therapeutic advantage and is focused on how blood vessels and brain cells communicate with each other.
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The Science of Stroke: Mechanisms in Search of Treatments
TL;DR: This review focuses on mechanisms and emerging concepts that drive the science of stroke in a therapeutic direction and poses a number of fundamental questions that may generate new directions for research and possibly new treatments that could reduce the impact of this enormous economic and societal burden.
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Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
Marc Fisher,Marc Fisher,Giora Z. Feuerstein,David W. Howells,Patricia D. Hurn,Thomas A. Kent,Sean I Savitz,Eng H. Lo +7 more
TL;DR: The updated STAIR preclinical recommendations reinforce the previous suggestions that reproducibly defining dose response and time windows with both histological and functional outcomes in multiple animal species with appropriate physiological monitoring is appropriate.
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Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia
Minoru Asahi,Xiaoying Wang,Tatsuro Mori,Toshihisa Sumii,Jae-Chang Jung,Michael A. Moskowitz,M. Elizabeth Fini,Eng H. Lo +7 more
TL;DR: Data demonstrate that the protective effects of MMP-9 gene knock-out after transient focal ischemia may be mediated by reduced proteolytic degradation of critical blood–brain barrier and white matter components.
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Transfer of mitochondria from astrocytes to neurons after stroke
Kazuhide Hayakawa,Elga Esposito,Xiaohua Wang,Xiaohua Wang,Yasukazu Terasaki,Yi Liu,Yi Liu,Changhong Xing,Xunming Ji,Eng H. Lo +9 more
TL;DR: It is shown that astrocytes in mice can also release functional mitochondria that enter neurons, suggesting a new mitochondrial mechanism of neuroglial crosstalk that may contribute to endogenous neuroprotective and neurorecovery mechanisms after stroke.