M
Miral Dizdaroglu
Researcher at National Institute of Standards and Technology
Publications - 237
Citations - 23998
Miral Dizdaroglu is an academic researcher from National Institute of Standards and Technology. The author has contributed to research in topics: DNA & DNA damage. The author has an hindex of 77, co-authored 232 publications receiving 22633 citations. Previous affiliations of Miral Dizdaroglu include University of London.
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Oxidative DNA damage: mechanisms, mutation, and disease
TL;DR: This review critically addresses the extent to which the in vitro significance of oxidative DNA damage has relevance for the pathogenesis of disease, drawing attention to the multiplicity of proteins with repair activities along with a number of poorly considered effects of damage.
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Oxidative DNA damage and disease: induction, repair and significance
TL;DR: The weight of evidence strongly suggests a link between such damage and the pathogenesis of disease, and the role of 8-OH-dG in disease, although exact roles remain to be elucidated.
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Free radical-induced damage to DNA: mechanisms and measurement.
TL;DR: Mechanistic aspects of oxidative damage to DNA and recent developments in the measurement of this type of damage using chromatographic and mass spectrometric techniques are reviewed.
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Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.
TL;DR: T4 RNA ligase was used to construct a deoxypentanucleotide containing a single 8-hydroxyguanine residue, which is one of the putatively mutagenic DNA adducts produced by oxidants and ionizing radiation.
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Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization.
TL;DR: Analysis of gamma-irradiated DNA after incubation with the FPG protein followed by precipitation revealed that the Fpg protein significantly excised 4,6-diamino-5-formamidopyrimidine (FapyAde), FapyGua, and 8-OH-Gua from visible light/MB-treated DNA.