S
Serge Boiteux
Researcher at Centre national de la recherche scientifique
Publications - 130
Citations - 11747
Serge Boiteux is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: DNA glycosylase & DNA repair. The author has an hindex of 60, co-authored 130 publications receiving 11406 citations. Previous affiliations of Serge Boiteux include French Alternative Energies and Atomic Energy Commission & Emory University.
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Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae
TL;DR: The results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the protection of the genome from the mutagenic effects of the oxidatively damaged purines.
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Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization.
TL;DR: Analysis of gamma-irradiated DNA after incubation with the FPG protein followed by precipitation revealed that the Fpg protein significantly excised 4,6-diamino-5-formamidopyrimidine (FapyAde), FapyGua, and 8-OH-Gua from visible light/MB-treated DNA.
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Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae
Serge Boiteux,Marie Guillet +1 more
TL;DR: The results in yeast demonstrate that AP sites are critical endogenous DNA damages that cause genetic instability and by analogy could be associated with degenerative pathologies in human.
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XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein–protein interactions
TL;DR: It is reported here that XRCC1, another essential protein involved in the maintenance of genome stability, physically interacts with APE1 and stimulates its enzymatic activities, extending the coordinating role of XR CC1 to the initial step of the repair of DNA abasic sites.
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The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis.
Serge Boiteux,J. Pablo Radicella +1 more
TL;DR: Results point to 8-OH-G as an endogenous source of mutations in eukaryotes and to its likely involvement in the process of carcinogenesis and to a possible role in the prevention of cancer.