M
Mirka Laavola
Researcher at University of Tampere
Publications - 11
Citations - 450
Mirka Laavola is an academic researcher from University of Tampere. The author has contributed to research in topics: Inflammation & Tumor necrosis factor alpha. The author has an hindex of 10, co-authored 11 publications receiving 357 citations.
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Journal ArticleDOI
TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse
Lauri J. Moilanen,Mirka Laavola,Meiju Kukkonen,Riku Korhonen,Tiina Leppänen,Edward D. Högestätt,Peter M. Zygmunt,Riina Nieminen,Eeva Moilanen +8 more
TL;DR: The results strongly suggest that TRPA1 contributes, in a COX-dependent manner, to the development of acute inflammation, and demonstrates a hitherto unknown role of TRPA 1 in carrageenan-induced inflammatory edema.
Journal ArticleDOI
Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo.
Mirka Laavola,Raisa Haavikko,Mari Hämäläinen,Tiina Leppänen,Riina Nieminen,Sami Alakurtti,Vânia M. Moreira,Vânia M. Moreira,Jari Yli-Kauhaluoma,Eeva Moilanen +9 more
TL;DR: The results show, for the first time, that the pyrazole-fused betulin derivative (9) and related compounds have anti-inflammatory properties that could be utilized in drug development.
Journal ArticleDOI
Flavonoids Eupatorin and Sinensetin Present in Orthosiphon stamineus Leaves Inhibit Inflammatory Gene Expression and STAT1 Activation
Mirka Laavola,Riina Nieminen,Mun Fei Yam,Mun Fei Yam,Amirin Sadikun,Mohd Zaini Asmawi,Rusliza Basir,Jukka Welling,Heikki Vapaatalo,Riku Korhonen,Eeva Moilanen +10 more
TL;DR: The results suggest that Orthosiphon stamineus leaf chloroform extract, as well as the known constituents of CF2, i.e., eupatorin and sinensetin, have meaningful anti-inflammatory properties which may be utilized in the development of novel anti- inflammation treatments.
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Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner.
Heikki Eräsalo,Mari Hämäläinen,Tiina Leppänen,Ilari Mäki-Opas,Mirka Laavola,Raisa Haavikko,Jari Yli-Kauhaluoma,Eeva Moilanen +7 more
TL;DR: The three most potent stilbenoids, piceatannol, pinosylvin, and pterostilbene, were found to suppress inflammatory edema and to down-regulate the production of inflammatory mediators IL6 and MCP1 in carrageenan-induced paw inflammation in mice.
Journal ArticleDOI
Pinosylvin and monomethylpinosylvin, constituents of an extract from the knot of Pinus sylvestris, reduce inflammatory gene expression and inflammatory responses in vivo.
TL;DR: Investigation of the anti-inflammatory effects of a knot extract from P. sylvestris and two stilbenes isolated reveal that the Scots pine stILbenes pinosylvin and monomethylpinosylvan are potential anti- inflammatory compounds.