M
Mitchell G. Thompson
Researcher at Joint BioEnergy Institute
Publications - 60
Citations - 1590
Mitchell G. Thompson is an academic researcher from Joint BioEnergy Institute. The author has contributed to research in topics: Pseudomonas putida & Acinetobacter baumannii. The author has an hindex of 17, co-authored 57 publications receiving 1162 citations. Previous affiliations of Mitchell G. Thompson include University of California, Berkeley & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
AB5075, a Highly Virulent Isolate of Acinetobacter baumannii, as a Model Strain for the Evaluation of Pathogenesis and Antimicrobial Treatments
Anna C. Jacobs,Mitchell G. Thompson,Chad C. Black,Jennifer L. Kessler,Lily P. Clark,Christin N. McQueary,Hanan Gancz,Brendan W. Corey,Jay K. Moon,Yuanzheng Si,Matthew T. Owen,Justin D. Hallock,Yoon I. Kwak,Amy Summers,Charles Z. Li,David A. Rasko,William F. Penwell,Cary L. Honnold,Matthew C. Wise,Paige E. Waterman,Emil Lesho,Rena L. Stewart,Luis A. Actis,Thomas J. Palys,David Craft,Daniel V. Zurawski +25 more
TL;DR: It is proposed that AB5075 can serve as a model strain for A. baumannii pathogenesis due to its relatively recent isolation, multidrug resistance, reproducible virulence in animal models, and genetic tractability.
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Personalized Therapeutic Cocktail of Wild Environmental Phages Rescues Mice from Acinetobacter baumannii Wound Infections
James Regeimbal,Anna C. Jacobs,Brendan W. Corey,Matthew Henry,Mitchell G. Thompson,Rebecca L. Pavlicek,Javier Quinones,Ryan M. Hannah,Meron Ghebremedhin,Nicole J. Crane,Daniel V. Zurawski,Nimfa Teneza-Mora,Biswajit Biswas,Eric R. Hall +13 more
TL;DR: A five-member cocktail of wild phages against Acinetobacter baumannii is isolated and assembled and demonstrated therapeutic efficacy in a mouse full-thickness dorsal infected wound model, establishing a pipeline for developing new phage therapeutics against additional clinically relevant multidrug-resistant pathogens by using environmental phages sourced from around the globe.
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Metabolic engineering for the high-yield production of isoprenoid-based C₅ alcohols in E. coli.
Kevin W. George,Mitchell G. Thompson,Aram Kang,Edward E. K. Baidoo,G. Wang,Leanne Jade G. Chan,Paul D. Adams,Christopher J. Petzold,Jay D. Keasling,Taek Soon Lee +9 more
TL;DR: This study engineered a heterologous isoprenoid pathway in E. coli for the high-yield production of 3- methyl-3-buten-1-ol, 3-methyl-2-butens-1 -ol, and 3-ethyl- 1-butanol, three C5 alcohols that serve as potential biofuels.
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Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens
TL;DR: Iron chelators evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect.
Journal ArticleDOI
Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity in isoprenoid-producing Escherichia coli.
Kevin W. George,Mitchell G. Thompson,Joonhoon Kim,Edward E. K. Baidoo,George Wang,Veronica Teixeira Benites,Christopher J. Petzold,Leanne Jade G. Chan,Suzan Yilmaz,Petri A. Turhanen,Paul D. Adams,Jay D. Keasling,Taek Soon Lee +12 more
TL;DR: A comprehensive assessment of IPP stress suggests potential strategies for the alleviation of prenyl diphosphate toxicity and highlights possible engineering targets for improved IPP flux and high titer isoprenoid production.