Mitsunobu Murata

TL;DR: In older hypertensives, a higher morning BP surge is associated with stroke risk independently of ambulatory BP, nocturnal BP falls, and silent infarct, and reduction of the MS could be a new therapeutic target for preventing target organ damage and subsequent cardiovascular events in hypertensive patients.

TL;DR: During a median 55 months of follow-up, Kaplan-Meier analysis revealed that the SDB group had a significantly higher rate of cardiovascular events and all-cause mortality than the normal group.

TL;DR: Results indicate that cAMP upregulates cytokine-induced iNOS expression in cardiac myocytes, and the synergistic effect of cAMP on IL-1 beta-induced nitrite accumulation was mimicked by cAMP-generating agonists forskolin and isoproterenol.

TL;DR: There was no change in arterial stiffness (based on CAVI) during treatment with luseogliflozin, but changes in BP and metabolic parameters were consistent with the known beneficial effects of SGLT2 inhibitors in T2DM.

TL;DR: Thyroid hormone directly increases cardiac Na(+)-Ca2+ exchanger expression, independent of alterations in Na+ mobilization, and these findings suggest also that thyroid hormone and Na+ regulate Na(-Ca2- exchanger gene expression through distinct molecular regulatory pathways.