Shigeaki Muto

TL;DR: It is concluded that claudin-2 constitutes leaky and cation (Na+)–selective paracellular channels within tight junctions of mouse proximal tubules, which possess a leaky epithelium whose unique permeability properties underlie their high rate of NaCl reabsorption.

TL;DR: Results indicate that Six1 functions as a key regulator of otic vesicle patterning at early embryogenesis and controls the expression domains of downstream otic genes responsible for respective inner ear structures.

TL;DR: Streptozotocin-induced renal fibrosis, PAI-1 expression, TGF-beta1expression, and macrophage infiltration occur via mineralocorticoid receptor, and spironolactone ameliorates renal Fibrosis presumably via the inhibition of macrophages infiltration, PAi- 1 expression, and TGF -beta1 expression in streptozosotocIn-induced early diabetic injury.

TL;DR: The amount of urinary Klotho, rather than the serum Klotha levels, should be linked to the magnitude of the functioning nephrons in CKD patients, as well as the estimated glomerular filtration rate.

TL;DR: By cable analysis and intracellular microelectrode impalement in the in vitro perfused renal tubule, alpha- and beta-intercalated (IC) cells along the rabbit distal nephron segments are identified, suggesting that the beta type predominates in the earlier segment and the alpha type in the later segment.