M
MJ Griffin
Researcher at Newcastle University
Publications - 25
Citations - 1273
MJ Griffin is an academic researcher from Newcastle University. The author has contributed to research in topics: Pharmacokinetics & Carboplatin. The author has an hindex of 15, co-authored 25 publications receiving 1165 citations.
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Journal ArticleDOI
A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours
Ruth Plummer,Richard H. Wilson,H. Calvert,Alan V. Boddy,MJ Griffin,Julieann Sludden,Michael J. Tilby,Martin Eatock,D.G. Pearson,Chris J. Ottley,Yasuhiro Matsumura,Kazunori Kataoka,T. Nishiya +12 more
TL;DR: The delayed and sustained release of cisplatin after i.v. administration contributes to the low toxicity of NC-6004 and the recommended dose was 90 mg m−2, although DLT was not defined as per protocol.
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Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide
Johanne Bray,Julieann Sludden,MJ Griffin,Michael Cole,Mark Verrill,David Jamieson,Alan V. Boddy +6 more
TL;DR: Variant alleles in the ABCB1, SLC22A16 and CYP2B6 genes are associated with response to AC therapy in the treatment of breast cancer and were associated with a worse outcome.
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Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma
Andy Hughes,Paula Calvert,Ashraf Azzabi,Ruth Plummer,Robert Johnson,James J. Rusthoven,MJ Griffin,K Fishwick,Alan V. Boddy,Mark Verrill,Hilary Calvert +10 more
TL;DR: The maximum tolerated dose (MTD) of pemetrexed and carboplatin given in combination is both active and well tolerated in MPM and deserves further exploration.
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A phase I and pharmacokinetic study of paclitaxel poliglumex (XYOTAX), investigating both 3-weekly and 2-weekly schedules.
Alan V. Boddy,Elizabeth Ruth Plummer,R Todd,Julieann Sludden,MJ Griffin,Lisa Robson,Jim Cassidy,Donald Bissett,A Bernareggi,Mark Verrill,Alan Hilary Calvert +10 more
TL;DR: PPX is a water-soluble paclitaxel-polymer conjugate with a prolonged half-life and limited volume of distribution and dose-limiting toxicities were neutropenia and neuropathy.
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Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.
Ruth Plummer,Laura Vidal,MJ Griffin,Mark Lesley,Johann S. de Bono,Sally A. Coulthard,Julieann Sludden,Lillian L. Siu,Eric Chen,Amit M. Oza,Gregory K. Reid,A. Robert McLeod,Jeffrey M. Besterman,C. Lee,Ian Judson,Hilary Calvert,Alan V. Boddy +16 more
TL;DR: MG98 was well tolerated with mild fatigue and myalgia, dose-limiting toxicity was asymptomatic transaminitis, and the maximum tolerated dose was 200 mg/m2/d; proof of mechanism was observed and measurement of DNMT1 expression in peripheral blood mononuclear cells may be useful in future phase II development.