Mohamad J. Halawi

TL;DR: DNase-chip is described, an approach that can rapidly identify DNase I hypersensitive sites for any region of interest, or potentially for the entire genome, by using tiled microarrays and can be applied globally or in a targeted fashion to any tissue from any species with a sequenced genome.

TL;DR: The genomic binding sites of menin, MLL1, and Rbbp5, to approximately 20,000 promoters in HeLa S3, HepG2, and pancreatic islet cells are mapped using the strategy of chromatin-immunoprecipitation coupled with microarray analysis and suggest that menin functions as a general regulator of transcription.

TL;DR: Preoperative optimization of medical comorbidities is crucial given the relatively high complication rate and there are several limitations with currently used outcome measures that prevent a well-informed discussion on the outcomes after surgery.

TL;DR: While persistent pain and functional limitation are the 2 leading reasons for dissatisfaction in both TKA and THA, a subset of patients view satisfaction as an evaluation of the process by which care is delivered.

TL;DR: An extensive review of traditional and modern perioperative interventions in pain management for total joint arthroplasty, including intravenous patient-controlled analgesia, epidural infusion, oral opioids, nonsteroidal anti-inflammatory drugs, acetaminophen, peripheral nerve blocks, periarticular infiltration, steroids, anticonvulsants, and long-acting local anesthetics are provided.